Comparison of transfusion burden and pretransfusion laboratory parameters before and after the addition of hydroxyurea to chronic transfusion
| . | 1 y before start of hydroxyurea . | 1 y after HAT-TD . | Change . | P* . |
|---|---|---|---|---|
| Total RBC volume, mL | ||||
| Patient02 | 6087 | 5995 | −92 | |
| Patient06 | 3887 | 3409 | −478 | |
| Total RBC volume/weight, mL/kg | ||||
| Patient02 | 268.3 | 234.1 | −34.2 | |
| Patient06 | 155.6 | 126.3 | −29.3 | |
| Transfusion events, n | ||||
| Patient02 | 24 | 25 | +1 | |
| Patient06 | 14 | 14 | 0 | |
| Hb S, median (IQR), % | ||||
| Patient02 | 16.4 (11.4-23.5) | 25 (20.6-29.7) | +8.6 | .001 |
| Patient06 | 28.1 (22.2-35.5) | 44 (33.9-49.1) | +15.9 | .017 |
| Hb F, median (IQR), % | ||||
| Patient02 | 2.9 (2.4-4.4) | 16.1 (14.1-17.6) | +13.2 | <.0001 |
| Patient06 | 1.3 (0.5-2.4) | 13.1 (9.6-16.1) | +11.8 | <.0001 |
| Total Hb, median (IQR), g/dL | ||||
| Patient02 | 8.9 (8.6-9.4) | 9.4 (9.1-10.1) | +0.5 | .0006 |
| Patient06 | 8.1 (7.8-8.5) | 9.5 (8.5-10.0) | +1.4 | .001 |
| LDH, median (IQR), unit/L | ||||
| Patient02 | 842 (701-956) | 531 (383-779) | −311 | .0005 |
| Patient06 | 976 (869-1289) | 521 (505-640) | −455 | <.0001 |
| . | 1 y before start of hydroxyurea . | 1 y after HAT-TD . | Change . | P* . |
|---|---|---|---|---|
| Total RBC volume, mL | ||||
| Patient02 | 6087 | 5995 | −92 | |
| Patient06 | 3887 | 3409 | −478 | |
| Total RBC volume/weight, mL/kg | ||||
| Patient02 | 268.3 | 234.1 | −34.2 | |
| Patient06 | 155.6 | 126.3 | −29.3 | |
| Transfusion events, n | ||||
| Patient02 | 24 | 25 | +1 | |
| Patient06 | 14 | 14 | 0 | |
| Hb S, median (IQR), % | ||||
| Patient02 | 16.4 (11.4-23.5) | 25 (20.6-29.7) | +8.6 | .001 |
| Patient06 | 28.1 (22.2-35.5) | 44 (33.9-49.1) | +15.9 | .017 |
| Hb F, median (IQR), % | ||||
| Patient02 | 2.9 (2.4-4.4) | 16.1 (14.1-17.6) | +13.2 | <.0001 |
| Patient06 | 1.3 (0.5-2.4) | 13.1 (9.6-16.1) | +11.8 | <.0001 |
| Total Hb, median (IQR), g/dL | ||||
| Patient02 | 8.9 (8.6-9.4) | 9.4 (9.1-10.1) | +0.5 | .0006 |
| Patient06 | 8.1 (7.8-8.5) | 9.5 (8.5-10.0) | +1.4 | .001 |
| LDH, median (IQR), unit/L | ||||
| Patient02 | 842 (701-956) | 531 (383-779) | −311 | .0005 |
| Patient06 | 976 (869-1289) | 521 (505-640) | −455 | <.0001 |
IQR, interquartile range, LDH, lactate dehydrogenase.
Mann-Whitney test, before hydroxyurea vs after hydroxyurea at target dose.