Table 1. TA-TMA diagnostic criteria used... | American Society of Hematology

Table 1.

TA-TMA diagnostic criteria used

Category	Cho criteria (5/5)	Jodele criteria (4/7)
Presence of schistocytes	X	X
Increased LDH	X	X
Thrombocytopenia or need for platelet transfusions	X	X
Anemia or required RBC transfusions	X	X
Negative Coombs test	X
Other	No coagulopathy	HTN >99th percentile for age (<18 y) or 140/90 mm Hg (>18 y) or needing ≥2 antihypertensive medications
Proteinuria		≥30 mg/dL on random UA*
Terminal complement activation		Plasma sC5b-9 above normal (≥244 ng/mL)*

Category	Cho criteria (5/5)	Jodele criteria (4/7)
Presence of schistocytes	X	X
Increased LDH	X	X
Thrombocytopenia or need for platelet transfusions	X	X
Anemia or required RBC transfusions	X	X
Negative Coombs test	X
Other	No coagulopathy	HTN >99th percentile for age (<18 y) or 140/90 mm Hg (>18 y) or needing ≥2 antihypertensive medications
Proteinuria		≥30 mg/dL on random UA*
Terminal complement activation		Plasma sC5b-9 above normal (≥244 ng/mL)*

RBC, red blood cell; UA, urinanalysis; X, required.

Presence of proteinuria and elevated complement are described as high-risk features with OS <80% in a historic untreated cohort.¹¹