Summary of dose-limiting toxicities
| Dose (mg/kg) . | Toxicity . | Grade . | Outcome . |
|---|---|---|---|
| 1.0 | Sepsis with acute respiratory distress syndrome | 5 | Fatal |
| 1.0 | APLS with CVA | 5 | Fatal |
| 0.5 | GVHD (liver and gut) | 5 | Fatal |
| 0.5 | GVHD (liver and gut) | 5 | Fatal |
| 0.5 | Elevated bilirubin | 3 | Resolved after >4 wk with drug hold, steroids |
| 0.5 | Transaminitis | 3 | Resolved after >4 wk with drug hold, steroids |
| Dose (mg/kg) . | Toxicity . | Grade . | Outcome . |
|---|---|---|---|
| 1.0 | Sepsis with acute respiratory distress syndrome | 5 | Fatal |
| 1.0 | APLS with CVA | 5 | Fatal |
| 0.5 | GVHD (liver and gut) | 5 | Fatal |
| 0.5 | GVHD (liver and gut) | 5 | Fatal |
| 0.5 | Elevated bilirubin | 3 | Resolved after >4 wk with drug hold, steroids |
| 0.5 | Transaminitis | 3 | Resolved after >4 wk with drug hold, steroids |
APLS, antiphospholipid syndrome; CVA, cerebrovascular accident.