Unadjusted outcome rates (uncapped vs capped dosing) at 15 days in patients initiated on LMWH and transitioned to other agents
| . | Capped dose . | Uncapped dose . | OR (95% CI) . | P . |
|---|---|---|---|---|
| Patients, n | 454 | 2392 | ||
| 15-d outcome, n (%) | ||||
| Recurrent PE | 2 (0.44) | 5 (0.21) | 2.11 (0.41-10.9) | .310 |
| Recurrent DVT | 0 (0) | 4 (0.17) | — | >.99 |
| Recurrent VTE | 2 (0.44) | 9 (0.38) | 1.17 (0.25-5.44) | .691 |
| Major bleeding | 0 (0) | 26 (1.1) | — | .026 |
| Gastrointestinal | 0 (0) | 6 (0.25) | — | .598 |
| Hematoma | 0 (0) | 5 (0.21) | — | >.99 |
| Intracranial | 0 (0) | 4 (0.17) | — | >.99 |
| Recurrent VTE or major bleeding | 2 (0.44) | 35 (1.5) | 0.30 (0.07-1.24) | .109 |
| Death | 1 (0.22) | 21 (0.88) | 0.25 (0.03-1.86) | .237 |
| Cause of death, n (%) | ||||
| Pulmonary embolism | 1 (0.22) | 9 (0.38) | 0.58 (0.07-4.62) | >.99 |
| Sudden, unexpected | 0 (0) | 2 (0.08) | — | >.99 |
| Bleeding | 0 (0) | 1 (0.04) | — | >.99 |
| Disseminated cancer | 0 (0) | 3 (0.13) | — | >.99 |
| Ischemic stroke | 0 (0) | 2 (0.08) | — | >.99 |
| Composite outcome | 2 (0.44) | 2 (2.2) | 0.20 (0.05-0.82) | .008 |
| . | Capped dose . | Uncapped dose . | OR (95% CI) . | P . |
|---|---|---|---|---|
| Patients, n | 454 | 2392 | ||
| 15-d outcome, n (%) | ||||
| Recurrent PE | 2 (0.44) | 5 (0.21) | 2.11 (0.41-10.9) | .310 |
| Recurrent DVT | 0 (0) | 4 (0.17) | — | >.99 |
| Recurrent VTE | 2 (0.44) | 9 (0.38) | 1.17 (0.25-5.44) | .691 |
| Major bleeding | 0 (0) | 26 (1.1) | — | .026 |
| Gastrointestinal | 0 (0) | 6 (0.25) | — | .598 |
| Hematoma | 0 (0) | 5 (0.21) | — | >.99 |
| Intracranial | 0 (0) | 4 (0.17) | — | >.99 |
| Recurrent VTE or major bleeding | 2 (0.44) | 35 (1.5) | 0.30 (0.07-1.24) | .109 |
| Death | 1 (0.22) | 21 (0.88) | 0.25 (0.03-1.86) | .237 |
| Cause of death, n (%) | ||||
| Pulmonary embolism | 1 (0.22) | 9 (0.38) | 0.58 (0.07-4.62) | >.99 |
| Sudden, unexpected | 0 (0) | 2 (0.08) | — | >.99 |
| Bleeding | 0 (0) | 1 (0.04) | — | >.99 |
| Disseminated cancer | 0 (0) | 3 (0.13) | — | >.99 |
| Ischemic stroke | 0 (0) | 2 (0.08) | — | >.99 |
| Composite outcome | 2 (0.44) | 2 (2.2) | 0.20 (0.05-0.82) | .008 |