Table 2. Comparison of full JOS... | American Society of Hematology

Table 2.

Comparison of full JOS population and JOS-C subset

	JOS*†		JOS-C subset‡
	Prophylaxis	Episodic	Early prophy	Delayed prophy
Bleeds prior to JOS entry, mean (range)
Total joint bleeds	1.0 (0-5)	0.6 (0-3)	0.8 (0-3)	0.4 (0-3)
Total bleeds	6.2 (0-35)	6.8 (0-32)	8.1 (0-35)	8.1 (0-32)
Annualized bleeds at age 6 y, mean (SD)
Joint bleeds	0.6 (1.4)	4.9 (3.57)	0.7 (0.8)	3.8 (2.8)
Total bleeds	3.3 (6.2)	17.7 (9.3)	3.2 (3.1)	14.4 (6.6)

	JOS*†		JOS-C subset‡
	Prophylaxis	Episodic	Early prophy	Delayed prophy
Bleeds prior to JOS entry, mean (range)
Total joint bleeds	1.0 (0-5)	0.6 (0-3)	0.8 (0-3)	0.4 (0-3)
Total bleeds	6.2 (0-35)	6.8 (0-32)	8.1 (0-35)	8.1 (0-32)
Annualized bleeds at age 6 y, mean (SD)
Joint bleeds	0.6 (1.4)	4.9 (3.57)	0.7 (0.8)	3.8 (2.8)
Total bleeds	3.3 (6.2)	17.7 (9.3)	3.2 (3.1)	14.4 (6.6)

Data from Manco-Johnson et al.⁴

For JOS, relative risk of MRI OC damage at age 6 years (episodic/prophylaxis) was 6.1 (95% CI, 1.5, 24.4).

For the JOS-C subset, relative risk of MRI OC damage at age 6 years (episodic/prophylaxis) was 6.09 (95% CI, 0.92-40.21).