COVID-19–associated coagulopathy
| Summary of findings . |
|---|
| 1. Coagulopathy is manifest as elevated fibrinogen, elevated D-dimers, and minimal change in PT, aPTT, and platelet count in early stages of infection |
| 2. Increasing IL-6 levels are correlated with increasing fibrinogen levels |
| 3. Coagulopathy appears to be related to severity of illness and resultant thromboinflammation and not intrinsic viral activity |
| 4. Elevated D-dimer at admission is associated with increased mortality |
| 5. Rising D-dimer after admission precedes multiorgan failure and overt DIC |
| a. Noted to start at 4 d after admission in nonsurvivors |
| b. Longer duration of hospital stay associated with increasing D-dimer and development of sepsis physiology |
| 6. Bleeding manifestations are not common despite coagulopathy |
| Summary of findings . |
|---|
| 1. Coagulopathy is manifest as elevated fibrinogen, elevated D-dimers, and minimal change in PT, aPTT, and platelet count in early stages of infection |
| 2. Increasing IL-6 levels are correlated with increasing fibrinogen levels |
| 3. Coagulopathy appears to be related to severity of illness and resultant thromboinflammation and not intrinsic viral activity |
| 4. Elevated D-dimer at admission is associated with increased mortality |
| 5. Rising D-dimer after admission precedes multiorgan failure and overt DIC |
| a. Noted to start at 4 d after admission in nonsurvivors |
| b. Longer duration of hospital stay associated with increasing D-dimer and development of sepsis physiology |
| 6. Bleeding manifestations are not common despite coagulopathy |