COVID-19–associated coagulopathy
Summary of findings . |
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1. Coagulopathy is manifest as elevated fibrinogen, elevated D-dimers, and minimal change in PT, aPTT, and platelet count in early stages of infection |
2. Increasing IL-6 levels are correlated with increasing fibrinogen levels |
3. Coagulopathy appears to be related to severity of illness and resultant thromboinflammation and not intrinsic viral activity |
4. Elevated D-dimer at admission is associated with increased mortality |
5. Rising D-dimer after admission precedes multiorgan failure and overt DIC |
a. Noted to start at 4 d after admission in nonsurvivors |
b. Longer duration of hospital stay associated with increasing D-dimer and development of sepsis physiology |
6. Bleeding manifestations are not common despite coagulopathy |
Summary of findings . |
---|
1. Coagulopathy is manifest as elevated fibrinogen, elevated D-dimers, and minimal change in PT, aPTT, and platelet count in early stages of infection |
2. Increasing IL-6 levels are correlated with increasing fibrinogen levels |
3. Coagulopathy appears to be related to severity of illness and resultant thromboinflammation and not intrinsic viral activity |
4. Elevated D-dimer at admission is associated with increased mortality |
5. Rising D-dimer after admission precedes multiorgan failure and overt DIC |
a. Noted to start at 4 d after admission in nonsurvivors |
b. Longer duration of hospital stay associated with increasing D-dimer and development of sepsis physiology |
6. Bleeding manifestations are not common despite coagulopathy |