Table 1.

COVID-19associated coagulopathy

Summary of findings
1. Coagulopathy is manifest as elevated fibrinogen, elevated D-dimers, and minimal change in PT, aPTT, and platelet count in early stages of infection 
2. Increasing IL-6 levels are correlated with increasing fibrinogen levels 
3. Coagulopathy appears to be related to severity of illness and resultant thromboinflammation and not intrinsic viral activity 
4. Elevated D-dimer at admission is associated with increased mortality 
5. Rising D-dimer after admission precedes multiorgan failure and overt DIC 
 a. Noted to start at 4 d after admission in nonsurvivors 
 b. Longer duration of hospital stay associated with increasing D-dimer and development of sepsis physiology 
6. Bleeding manifestations are not common despite coagulopathy 
Summary of findings
1. Coagulopathy is manifest as elevated fibrinogen, elevated D-dimers, and minimal change in PT, aPTT, and platelet count in early stages of infection 
2. Increasing IL-6 levels are correlated with increasing fibrinogen levels 
3. Coagulopathy appears to be related to severity of illness and resultant thromboinflammation and not intrinsic viral activity 
4. Elevated D-dimer at admission is associated with increased mortality 
5. Rising D-dimer after admission precedes multiorgan failure and overt DIC 
 a. Noted to start at 4 d after admission in nonsurvivors 
 b. Longer duration of hospital stay associated with increasing D-dimer and development of sepsis physiology 
6. Bleeding manifestations are not common despite coagulopathy 
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