Genes significantly more highly expressed in PBMCs after mogamulizumab treatment in patients with EM relative to those without this skin-related AE
| Gene . | With EM, mean (n = 16) . | Without EM, mean (n = 8) . | All patients, mean (N = 24) . | Fold change* . | P . |
|---|---|---|---|---|---|
| HLA-G | 2.00 | 0.55 | 1.52 | 3.63 | .004 |
| HLA-DMB | 476.82 | 163.61 | 372.42 | 2.91 | .016 |
| RORC | 21.42 | 9.12 | 17.32 | 2.35 | .007 |
| IL-4 | 1.97 | 0.86 | 1.60 | 2.29 | .027 |
| NCF1 | 22 334.37 | 10 101.82 | 18 256.85 | 2.21 | .000 |
| LCK | 71.35 | 33.56 | 58.75 | 2.13 | .010 |
| CXCR3 | 40.33 | 19.60 | 33.42 | 2.06 | .012 |
| IL3RA | 201.29 | 103.55 | 168.71 | 1.94 | .015 |
| CD40LG | 116.39 | 60.03 | 97.60 | 1.94 | .004 |
| PDCD1 | 154.08 | 83.86 | 130.67 | 1.84 | .015 |
| ADORA2A | 471.79 | 265.51 | 403.03 | 1.78 | .001 |
| CXCR6 | 108.23 | 61.13 | 92.53 | 1.77 | .030 |
| CCR1 | 3 147.59 | 1 798.45 | 2 697.87 | 1.75 | .041 |
| VEGFA | 249.29 | 144.04 | 214.21 | 1.73 | .029 |
| CD74 | 11 038.31 | 6 637.35 | 9 571.32 | 1.66 | .001 |
| STAT5A | 2 291.26 | 1 397.54 | 1 993.35 | 1.64 | .000 |
| HLA-DMA | 2 727.14 | 1 688.99 | 2 381.09 | 1.61 | .005 |
| CSF2RB | 3 929.13 | 2 520.22 | 3 459.49 | 1.56 | .036 |
| G6PD | 3 277.55 | 2 124.87 | 2 893.32 | 1.54 | .001 |
| LILRB2 | 7 224.99 | 4 722.22 | 6 390.73 | 1.53 | .046 |
| ITGB2 | 42 326.70 | 28 180.05 | 37 611.15 | 1.50 | .012 |
| IL-15 | 202.46 | 137.13 | 180.69 | 1.48 | .023 |
| HLA-F | 958.87 | 691.52 | 869.75 | 1.39 | .011 |
| BCL2L11 | 825.83 | 634.00 | 761.88 | 1.30 | .019 |
| IRF1 | 8 141.69 | 6 464.31 | 7 582.56 | 1.26 | .047 |
| C10orf54 | 11 103.42 | 8 816.11 | 10 340.99 | 1.26 | .030 |
| TNFRSF14 | 2 359.13 | 1 936.01 | 2 218.09 | 1.22 | .040 |
| Gene . | With EM, mean (n = 16) . | Without EM, mean (n = 8) . | All patients, mean (N = 24) . | Fold change* . | P . |
|---|---|---|---|---|---|
| HLA-G | 2.00 | 0.55 | 1.52 | 3.63 | .004 |
| HLA-DMB | 476.82 | 163.61 | 372.42 | 2.91 | .016 |
| RORC | 21.42 | 9.12 | 17.32 | 2.35 | .007 |
| IL-4 | 1.97 | 0.86 | 1.60 | 2.29 | .027 |
| NCF1 | 22 334.37 | 10 101.82 | 18 256.85 | 2.21 | .000 |
| LCK | 71.35 | 33.56 | 58.75 | 2.13 | .010 |
| CXCR3 | 40.33 | 19.60 | 33.42 | 2.06 | .012 |
| IL3RA | 201.29 | 103.55 | 168.71 | 1.94 | .015 |
| CD40LG | 116.39 | 60.03 | 97.60 | 1.94 | .004 |
| PDCD1 | 154.08 | 83.86 | 130.67 | 1.84 | .015 |
| ADORA2A | 471.79 | 265.51 | 403.03 | 1.78 | .001 |
| CXCR6 | 108.23 | 61.13 | 92.53 | 1.77 | .030 |
| CCR1 | 3 147.59 | 1 798.45 | 2 697.87 | 1.75 | .041 |
| VEGFA | 249.29 | 144.04 | 214.21 | 1.73 | .029 |
| CD74 | 11 038.31 | 6 637.35 | 9 571.32 | 1.66 | .001 |
| STAT5A | 2 291.26 | 1 397.54 | 1 993.35 | 1.64 | .000 |
| HLA-DMA | 2 727.14 | 1 688.99 | 2 381.09 | 1.61 | .005 |
| CSF2RB | 3 929.13 | 2 520.22 | 3 459.49 | 1.56 | .036 |
| G6PD | 3 277.55 | 2 124.87 | 2 893.32 | 1.54 | .001 |
| LILRB2 | 7 224.99 | 4 722.22 | 6 390.73 | 1.53 | .046 |
| ITGB2 | 42 326.70 | 28 180.05 | 37 611.15 | 1.50 | .012 |
| IL-15 | 202.46 | 137.13 | 180.69 | 1.48 | .023 |
| HLA-F | 958.87 | 691.52 | 869.75 | 1.39 | .011 |
| BCL2L11 | 825.83 | 634.00 | 761.88 | 1.30 | .019 |
| IRF1 | 8 141.69 | 6 464.31 | 7 582.56 | 1.26 | .047 |
| C10orf54 | 11 103.42 | 8 816.11 | 10 340.99 | 1.26 | .030 |
| TNFRSF14 | 2 359.13 | 1 936.01 | 2 218.09 | 1.22 | .040 |
Gene expression is presented as RPM.
Fold change is indicated as “with EM/without EM.”