Characteristics of the training cohort
| Variable . | UEP (N = 333) . | ||
|---|---|---|---|
| N . | % . | Missing . | |
| Age >65 years | 208 | 62.4 | — |
| Male sex | 178 | 53.4 | — |
| Palpable lymph nodes | 68 | 20.4 | — |
| Palpable spleen | 20 | 6.0 | — |
| Lymphocytes >15 × 109/L | 65 | 19.5 | — |
| Hb <13 g/dL (male)/<12 g/dL (female) | 39 | 11.7 | — |
| Platelets <150 × 109/L | 46 | 13.8 | — |
| B2M >3.5 mg/L | 32 | 9.6 | — |
| FISH normal | 112 | 33.6 | — |
| Del(13q) | 168 | 50.4 | — |
| Trisomy 12 | 59 | 17.7 | — |
| Del(11q) | 18 | 5.4 | — |
| Del(17p) | 19 | 5.7 | — |
| Unmutated IGHV | 92 | 27.6 | — |
| TP53 mutation | 24 | 7.2 | — |
| ATM mutation | 24 | 8.3 | 44 |
| MYD88 mutation | 18 | 5.4 | 4 |
| NOTCH1 mutation | 35 | 10.6 | 4 |
| SF3B1 mutation | 17 | 5.1 | 4 |
| CLL-IPI | |||
| Low risk | 182 | 54.7 | |
| Intermediate risk | 94 | 28.2 | |
| High risk | 45 | 13.5 | |
| Very high risk | 12 | 3.6 | |
| Variable . | UEP (N = 333) . | ||
|---|---|---|---|
| N . | % . | Missing . | |
| Age >65 years | 208 | 62.4 | — |
| Male sex | 178 | 53.4 | — |
| Palpable lymph nodes | 68 | 20.4 | — |
| Palpable spleen | 20 | 6.0 | — |
| Lymphocytes >15 × 109/L | 65 | 19.5 | — |
| Hb <13 g/dL (male)/<12 g/dL (female) | 39 | 11.7 | — |
| Platelets <150 × 109/L | 46 | 13.8 | — |
| B2M >3.5 mg/L | 32 | 9.6 | — |
| FISH normal | 112 | 33.6 | — |
| Del(13q) | 168 | 50.4 | — |
| Trisomy 12 | 59 | 17.7 | — |
| Del(11q) | 18 | 5.4 | — |
| Del(17p) | 19 | 5.7 | — |
| Unmutated IGHV | 92 | 27.6 | — |
| TP53 mutation | 24 | 7.2 | — |
| ATM mutation | 24 | 8.3 | 44 |
| MYD88 mutation | 18 | 5.4 | 4 |
| NOTCH1 mutation | 35 | 10.6 | 4 |
| SF3B1 mutation | 17 | 5.1 | 4 |
| CLL-IPI | |||
| Low risk | 182 | 54.7 | |
| Intermediate risk | 94 | 28.2 | |
| High risk | 45 | 13.5 | |
| Very high risk | 12 | 3.6 | |
B2M, β-2-microglobulin; Del, deletion; Hb, hemoglobin.