Table 4.

ORR at day 28 by baseline steroid-refractory status

ResponseGVHD progression after 3 d* (n = 19)No improvement in GVHD after 7 d* (n = 30)New GVHD (n = 8)Taper intolerant (n = 14)
CR 7 (36.8) 6 (20.0) 1 (12.5) 5 (35.7) 
VGPR 4 (21.1) 1 (3.3) 1 (12.5) 1 (7.1) 
PR 1 (5.3) 7 (23.3) 2 (25.5) 3 (21.4) 
Overall response 12 (63.2) 14 (46.7) 4 (50.0) 9 (64.3) 
 95% CI 38.4-83.7 28.3-65.7 15.7-84.3 35.1-87.2 
ResponseGVHD progression after 3 d* (n = 19)No improvement in GVHD after 7 d* (n = 30)New GVHD (n = 8)Taper intolerant (n = 14)
CR 7 (36.8) 6 (20.0) 1 (12.5) 5 (35.7) 
VGPR 4 (21.1) 1 (3.3) 1 (12.5) 1 (7.1) 
PR 1 (5.3) 7 (23.3) 2 (25.5) 3 (21.4) 
Overall response 12 (63.2) 14 (46.7) 4 (50.0) 9 (64.3) 
 95% CI 38.4-83.7 28.3-65.7 15.7-84.3 35.1-87.2 

Data are presented as n (%).

*

After primary treatment with methylprednisolone at least 2 mg/kg per day.

In another organ in patients who previously received corticosteroids (≥1 mg/kg per day methylprednisolone) for skin or skin plus upper GI GVHD.

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