Table 1. Previous studies assessing... | American Society of Hematology

Table 1.

Previous studies assessing association of ANAs with various outcomes in ITP patients

Study	Number of tested patients	Design	Threshold for ANA positivity	Prevalence, %	Outcomes
Kurata et al³	66 chronic ITP	Retrospective	1/40	44	No SLE and Sjögren syndrome during follow-up in the ANA⁺ group
Vantelon et al⁴	122 chronic ITP	Retrospective	1/40	13	2 SLEs during follow-up in the ANA⁺ group
Altintas et al⁵	108 newly diagnosed and chronic ITP	Retrospective	1/80	33.6	No difference regarding chronic evolution
Abbasi et al ⁶	46 newly diagnosed ITP	Retrospective	1/40	21.7	No difference regarding age, history of autoimmune disease, platelet count at diagnosis
Abbasi et al ⁶	46 newly diagnosed ITP	Retrospective	1/40	21.7	Response to corticosteroids less frequent if ANA⁺
Grimaldi-Bensouda et al⁷	136 newly diagnosed ITP	Prospective	1/80	25.7	No difference regarding age, sex, platelet count at diagnosis, chronic evolution
Grimaldi-Bensouda et al⁷	136 newly diagnosed ITP	Prospective	1/80	25.7	More frequent familial history of autoimmune disease and less frequent bleeding at diagnosis if ANA⁺
Moulis et al²	85 newly diagnosed ITP	Prospective	1/160	44.7	Risk for chronicity if ANA⁺ (OR, 2.89; 95% CI, 1.08-7.74)
Hollenhorst et al¹	144 ITP	Retrospective	1/40	65	Higher risk for thrombosis if ANA⁺
Hollenhorst et al¹	144 ITP	Retrospective	1/40	65	No difference in remission at last follow-up

Study	Number of tested patients	Design	Threshold for ANA positivity	Prevalence, %	Outcomes
Kurata et al³	66 chronic ITP	Retrospective	1/40	44	No SLE and Sjögren syndrome during follow-up in the ANA⁺ group
Vantelon et al⁴	122 chronic ITP	Retrospective	1/40	13	2 SLEs during follow-up in the ANA⁺ group
Altintas et al⁵	108 newly diagnosed and chronic ITP	Retrospective	1/80	33.6	No difference regarding chronic evolution
Abbasi et al ⁶	46 newly diagnosed ITP	Retrospective	1/40	21.7	No difference regarding age, history of autoimmune disease, platelet count at diagnosis
Abbasi et al ⁶	46 newly diagnosed ITP	Retrospective	1/40	21.7	Response to corticosteroids less frequent if ANA⁺
Grimaldi-Bensouda et al⁷	136 newly diagnosed ITP	Prospective	1/80	25.7	No difference regarding age, sex, platelet count at diagnosis, chronic evolution
Grimaldi-Bensouda et al⁷	136 newly diagnosed ITP	Prospective	1/80	25.7	More frequent familial history of autoimmune disease and less frequent bleeding at diagnosis if ANA⁺
Moulis et al²	85 newly diagnosed ITP	Prospective	1/160	44.7	Risk for chronicity if ANA⁺ (OR, 2.89; 95% CI, 1.08-7.74)
Hollenhorst et al¹	144 ITP	Retrospective	1/40	65	Higher risk for thrombosis if ANA⁺
Hollenhorst et al¹	144 ITP	Retrospective	1/40	65	No difference in remission at last follow-up

CI, confidence interval; OR, odds ratio.