Results from replication of fibrinogen and PAI-1 in FHS Gen3 cohort.
| Aging measure . | Hemostatic factor . | Model . | β . | SE . | LCI . | UCI . | P . |
|---|---|---|---|---|---|---|---|
| EEAD | Fibrinogen | Basic | 6.4 × 10−3 | 3.4 × 10−3 | −3.0 × 10−4 | 1.3 × 10−2 | .06 |
| IEAD | Fibrinogen | Basic | 4.0 × 10−3 | 4.5 × 10−3 | −4.7 × 10−3 | 1.3 × 10−2 | .37 |
| EEAD | Fibrinogen | Full | −8.6 × 10−5 | 3.2 × 10−3 | −6.4 × 10−3 | 6.2 × 10−3 | .98 |
| IEAD | Fibrinogen | Full | −8.6 × 10−5 | 4.2 × 10−3 | −8.3 × 10−3 | 8.1 × 10−3 | .98 |
| EEAD | PAI-1 | Basic | 0.17 | 0.05 | 0.07 | 0.28 | .001 |
| IEAD | PAI-1 | Basic | 0.16 | 0.07 | 0.03 | 0.29 | .01 |
| EEAD | PAI-1 | Full | 0.05 | 0.05 | −0.04 | 0.14 | .27 |
| IEAD | PAI-1 | Full | 0.09 | 0.06 | −0.03 | 0.20 | .16 |
| Aging measure . | Hemostatic factor . | Model . | β . | SE . | LCI . | UCI . | P . |
|---|---|---|---|---|---|---|---|
| EEAD | Fibrinogen | Basic | 6.4 × 10−3 | 3.4 × 10−3 | −3.0 × 10−4 | 1.3 × 10−2 | .06 |
| IEAD | Fibrinogen | Basic | 4.0 × 10−3 | 4.5 × 10−3 | −4.7 × 10−3 | 1.3 × 10−2 | .37 |
| EEAD | Fibrinogen | Full | −8.6 × 10−5 | 3.2 × 10−3 | −6.4 × 10−3 | 6.2 × 10−3 | .98 |
| IEAD | Fibrinogen | Full | −8.6 × 10−5 | 4.2 × 10−3 | −8.3 × 10−3 | 8.1 × 10−3 | .98 |
| EEAD | PAI-1 | Basic | 0.17 | 0.05 | 0.07 | 0.28 | .001 |
| IEAD | PAI-1 | Basic | 0.16 | 0.07 | 0.03 | 0.29 | .01 |
| EEAD | PAI-1 | Full | 0.05 | 0.05 | −0.04 | 0.14 | .27 |
| IEAD | PAI-1 | Full | 0.09 | 0.06 | −0.03 | 0.20 | .16 |
All aging measures were assessed in years while fibrinogen was measured in g/L and PAI-1 in U/mL. Replicated associations are given in bold. Basic model adjusted for age, age squared, and sex. Full model adjusted for age, age squared, sex, body mass index, smoking, and physical activity (where available). Additional linear and quadratic time difference terms were included in both models to represent the time between sample collection for the hemostatic factor assessment and assessment of DNA methylation. Effect estimates (β) are given per 1 year higher epigenetic age as compared with chronological age.
LCI, lower 95% confidence interval; UCI, upper 95% confidence interval.