Table 1. Significant meta-analysis... | American Society of Hematology

Table 1.

Significant meta-analysis associations between accelerated epigenetic aging and hemostatic factors

Outcome	Aging measure, y	Basic					Full
Outcome	Aging measure, y	β	SE	CI	P	P(Q)	β	SE	CI	P	P(Q)
PAI-1, U/mL	EEAD	0.18	0.04	0.11-0.25	2.4 × 10⁻⁷	0.10	0.13	0.03	0.07-0.20	6.6 × 10⁻⁵	.18
PAI-1, U/mL	IEAD	0.18	0.05	0.09-0.27	1.4 × 10⁻⁴	0.78	0.16	0.04	0.07-0.25	2.6 × 10⁻⁴	.79
Fibrinogen, g/L*	EEAD	0.01	0.002	0.002-0.009	.002	0.004	0.004	0.002	9.5E-04 to 0.007	.01	.03
aPTT, s	EEAD	−0.02	0.01	−0.04 to −0.007	.003	0.08	−0.02	0.01	−0.03 to −0.006	.005	.12

Outcome	Aging measure, y	Basic					Full
Outcome	Aging measure, y	β	SE	CI	P	P(Q)	β	SE	CI	P	P(Q)
PAI-1, U/mL	EEAD	0.18	0.04	0.11-0.25	2.4 × 10⁻⁷	0.10	0.13	0.03	0.07-0.20	6.6 × 10⁻⁵	.18
PAI-1, U/mL	IEAD	0.18	0.05	0.09-0.27	1.4 × 10⁻⁴	0.78	0.16	0.04	0.07-0.25	2.6 × 10⁻⁴	.79
Fibrinogen, g/L*	EEAD	0.01	0.002	0.002-0.009	.002	0.004	0.004	0.002	9.5E-04 to 0.007	.01	.03
aPTT, s	EEAD	−0.02	0.01	−0.04 to −0.007	.003	0.08	−0.02	0.01	−0.03 to −0.006	.005	.12

Basic and full model associations for hemostatic factor – epigenetic aging associations that were Bonferroni significant, P < 4.16 × 10⁻³, in the basic model associations. Effect estimates (β) are given per 1 year higher epigenetic age as compared with chronological age. Basic model adjusted for age, age squared, and sex. Full model adjusted for age, age squared, sex, body mass index, physical activity, and smoking. For fibrinogen estimates are given for the random effects meta-analysis.

β, effect estimate; CI, 95% confidence interval; EA, European ancestry population; P(Q), heterogeneity (Cochran’s Q) P value; SE, standard error.

Combined-race meta-analysis

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