Complications according to CTCAE, version 5.024
| Type . | Any grade . | Grade 3/4 . | Grade 5 . | |||
|---|---|---|---|---|---|---|
| . | DD . | DVD . | DD . | DVD . | DD . | DVD . |
| Infection | 37% (39) | 31% (19) | 16% (17) | 18% (11) | 6% (6) | 3% (2) |
| IRR | 7% (7) | 5% (3) | 2% (2) | — | — | — |
| CHF | NA | NA | 8% (9) | 10% (6) | NA | NA |
| Hyperglycemia | NA | NA | 3% (3) | — | — | — |
| Atrial fibrillation | 5% (5) | 6% (4) | — | — | — | — |
| Nausea | 4% (4) | 2% (1) | — | — | — | — |
| Diarrhea | 10% (11) | 2% (1) | 1% (1) | — | — | — |
| Polyneuropathy | — | 3% (2) | — | — | — | — |
| Other* | NA | NA | 4% (4) | 2% (1) | — | — |
| Lymphocytopenia | 53% (47/89) | 57% (30/53) | 20% (18/89) | 17% (9/53) | NA | NA |
| Neutropenia | 2% (2/90) | 0% (0/52) | — | — | — | — |
| Thrombocytopenia | 19% (18/94) | 22% (12/55) | 0% (0/94) | 2% (1/55) | — | — |
| Anemia | 50% (39/78) | 52% (29/56) | 3% (2/78) | 4% (2/56) | — | — |
| Type . | Any grade . | Grade 3/4 . | Grade 5 . | |||
|---|---|---|---|---|---|---|
| . | DD . | DVD . | DD . | DVD . | DD . | DVD . |
| Infection | 37% (39) | 31% (19) | 16% (17) | 18% (11) | 6% (6) | 3% (2) |
| IRR | 7% (7) | 5% (3) | 2% (2) | — | — | — |
| CHF | NA | NA | 8% (9) | 10% (6) | NA | NA |
| Hyperglycemia | NA | NA | 3% (3) | — | — | — |
| Atrial fibrillation | 5% (5) | 6% (4) | — | — | — | — |
| Nausea | 4% (4) | 2% (1) | — | — | — | — |
| Diarrhea | 10% (11) | 2% (1) | 1% (1) | — | — | — |
| Polyneuropathy | — | 3% (2) | — | — | — | — |
| Other* | NA | NA | 4% (4) | 2% (1) | — | — |
| Lymphocytopenia | 53% (47/89) | 57% (30/53) | 20% (18/89) | 17% (9/53) | NA | NA |
| Neutropenia | 2% (2/90) | 0% (0/52) | — | — | — | — |
| Thrombocytopenia | 19% (18/94) | 22% (12/55) | 0% (0/94) | 2% (1/55) | — | — |
| Anemia | 50% (39/78) | 52% (29/56) | 3% (2/78) | 4% (2/56) | — | — |
Percentages with numbers in parentheses. Percentages were calculated for all 106 patients receiving DD and all 62 patients receiving DVD unless otherwise stated. *Includes 3 patients receiving DD with transient ischemic attack/stroke, 1 patient receiving DD with a coronary infarction, and 1 patient receiving DVD with Leriche syndrome.
CHF, congestive heart failure; IRR, infusion-related reaction; NA, not assessed