Baseline characteristics of all study participants
| Characteristic . | No. of patients . | Value* . |
|---|---|---|
| Age, mean (SD) [range], y | 320 | 21 (21) [2-64] |
| Female sex, n (%) | 320 | 172 (54) |
| Prescribed hydroxyurea, n (%) | 320 | 145 (45) |
| On chronic transfusion, n (%) | 320 | 64 (20) |
| Systolic BP, mmHg | 302 | 110 (13) |
| Diastolic BP, mmHg | 302 | 63 (9) |
| ACR, mg/g | 303 | 82 (331) |
| Serum creatinine, mg/dL | 285 | 0.5 (0.2) |
| eGFR-CysC, mL/min/1.73 m2 | 259 | 141 (46) |
| eGFR-Cr, mL/min/1.73 m2 | 265 | 116 (32) |
| Urine osmolality, mOsm/kg | 297 | 430 (124) |
| Blood urea nitrogen, mg/dL | 287 | 9.2 (5) |
| Serum sodium, mmol/L | 256 | 139.5 (2.6) |
| Serum potassium, mmol/L | 255 | 4.3 (0.5) |
| Serum chloride, mmol/L | 255 | 105 (2.8) |
| NAG, U/g | 301 | 3.1 (3.3) |
| KIM-1, ng/g | 293 | 587 (745) |
| Hb, g/dL | 307 | 9 (1.3) |
| Reticulocyte count, % | 289 | 10.8 (5.5) |
| Total bilirubin, mg/dL | 281 | 3.2 (2.6) |
| LDH, U/L (normal, 135-359 U/L) | 93 | 1042 (614) |
| WBC count, ×109/L | 306 | 10.7 (4) |
| Platelet count, ×109/L | 304 | 391 (149) |
| HbF, % | 261 | 13 (11) |
| AST, U/L | 277 | 51 (25) |
| ALT, U/L | 238 | 28 (17) |
| Characteristic . | No. of patients . | Value* . |
|---|---|---|
| Age, mean (SD) [range], y | 320 | 21 (21) [2-64] |
| Female sex, n (%) | 320 | 172 (54) |
| Prescribed hydroxyurea, n (%) | 320 | 145 (45) |
| On chronic transfusion, n (%) | 320 | 64 (20) |
| Systolic BP, mmHg | 302 | 110 (13) |
| Diastolic BP, mmHg | 302 | 63 (9) |
| ACR, mg/g | 303 | 82 (331) |
| Serum creatinine, mg/dL | 285 | 0.5 (0.2) |
| eGFR-CysC, mL/min/1.73 m2 | 259 | 141 (46) |
| eGFR-Cr, mL/min/1.73 m2 | 265 | 116 (32) |
| Urine osmolality, mOsm/kg | 297 | 430 (124) |
| Blood urea nitrogen, mg/dL | 287 | 9.2 (5) |
| Serum sodium, mmol/L | 256 | 139.5 (2.6) |
| Serum potassium, mmol/L | 255 | 4.3 (0.5) |
| Serum chloride, mmol/L | 255 | 105 (2.8) |
| NAG, U/g | 301 | 3.1 (3.3) |
| KIM-1, ng/g | 293 | 587 (745) |
| Hb, g/dL | 307 | 9 (1.3) |
| Reticulocyte count, % | 289 | 10.8 (5.5) |
| Total bilirubin, mg/dL | 281 | 3.2 (2.6) |
| LDH, U/L (normal, 135-359 U/L) | 93 | 1042 (614) |
| WBC count, ×109/L | 306 | 10.7 (4) |
| Platelet count, ×109/L | 304 | 391 (149) |
| HbF, % | 261 | 13 (11) |
| AST, U/L | 277 | 51 (25) |
| ALT, U/L | 238 | 28 (17) |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase; WBC, white blood cell.
Values are expressed as mean (SD) unless otherwise noted.