Summary of CRS-related data by the Penn grading scale (n = 64 patients with CRS per the Penn scale)
| Variable . | Penn CRS grading scale . | Lee CRS grading scale . | ASTCT CRS grading criteria . | |||
|---|---|---|---|---|---|---|
| Grade 1-2 (n = 40) . | Grade 3-4 (n = 24) . | Grade 0-2* (n = 45) . | Grade 3-4 (n = 19) . | Grade 0-2* (n = 49) . | Grade 3-4 (n = 15) . | |
| High fever,† n (%)‡ | 36 (56.3) | 23 (35.9) | 41 (64.1) | 18 (28.1) | 44 (68.8) | 15 (23.4) |
| Patient admitted to ICU, n (%) | 6 (9.4) | 21 (32.8) | 10 (15.6) | 17 (26.6) | 13 (20.3) | 14 (21.9) |
| Hypotension that required intervention, n (%) | 10 (15.6) | 19 (29.7) | 13 (20.3) | 16 (25.0) | 15 (23.4) | 14 (21.9) |
| Fluid resuscitation used (≥40 cc/kg) | 10 (15.6) | 18 (28.1) | 13 (20.3) | 15 (23.4) | 15 (23.4) | 13 (20.3) |
| High-dose vasopressors used | 0 (0) | 7 (10.9) | 0 (0) | 7 (10.9) | 0 (0) | 7 (10.9) |
| Oxygen supplementation required, n (%) | 6 (9.4) | 21 (32.8) | 9 (14.1) | 18 (28.1) | 13 (20.3) | 14 (21.9) |
| Maximum % oxygen supplementation level, range | – | 35-100 | – | 35-100 | 0-60 | 35-100 |
| Maximum L/min oxygen supplementation level, range | 2-4 | 2-60 | 2-4 | 3-60 | 0-4 | 6-60 |
| Patient intubated, n (%) | 0 (0) | 8 (12.5) | 0 (0) | 8 (12.5) | 1 (1.6) | 7 (10.9) |
| Bleeding observed, n (%) | 2 (3.1) | 2 (3.1) | 2 (3.1) | 2 (3.1) | 3 (4.7) | 1 (1.6) |
| Concurrent infections, n (%) | 3 (4.7) | 4 (6.3) | 4 (6.3) | 3 (4.7) | 4 (6.3) | 3 (4.7) |
| Disseminated intravascular coagulation, n (%) | 0 (0) | 3 (4.7) | 0 (0) | 3 (4.7) | 1 (1.6) | 2 (3.1) |
| Pulmonary abnormalities, n (%) | 3 (4.7) | 12 (18.8) | 3 (4.7) | 12 (18.8) | 4 (6.3) | 11 (17.2) |
| Systemic anticytokine therapy given, n (%) | 1 (1.6) | 16 (25.0) | 3 (4.7) | 14 (21.9) | 5 (7.8) | 12 (18.8) |
| Corticosteroids used, n (%) | 1 (1.6) | 11 (17.2) | 2 (3.1) | 10 (15.6) | 4 (6.3) | 8 (12.5) |
| Tocilizumab used, n (%) | 0 (0) | 16 (25.0) | 2 (3.1) | 14 (21.9) | 4 (6.3) | 12 (18.8) |
| 1 dose | 0 (0) | 6 (9.4) | 1 (1.6) | 5 (7.8) | 1 (1.6) | 5 (7.8) |
| 2 doses | 0 (0) | 10 (15.6) | 1 (1.6) | 9 (14.1) | 3 (4.7) | 7 (10.9) |
| Variable . | Penn CRS grading scale . | Lee CRS grading scale . | ASTCT CRS grading criteria . | |||
|---|---|---|---|---|---|---|
| Grade 1-2 (n = 40) . | Grade 3-4 (n = 24) . | Grade 0-2* (n = 45) . | Grade 3-4 (n = 19) . | Grade 0-2* (n = 49) . | Grade 3-4 (n = 15) . | |
| High fever,† n (%)‡ | 36 (56.3) | 23 (35.9) | 41 (64.1) | 18 (28.1) | 44 (68.8) | 15 (23.4) |
| Patient admitted to ICU, n (%) | 6 (9.4) | 21 (32.8) | 10 (15.6) | 17 (26.6) | 13 (20.3) | 14 (21.9) |
| Hypotension that required intervention, n (%) | 10 (15.6) | 19 (29.7) | 13 (20.3) | 16 (25.0) | 15 (23.4) | 14 (21.9) |
| Fluid resuscitation used (≥40 cc/kg) | 10 (15.6) | 18 (28.1) | 13 (20.3) | 15 (23.4) | 15 (23.4) | 13 (20.3) |
| High-dose vasopressors used | 0 (0) | 7 (10.9) | 0 (0) | 7 (10.9) | 0 (0) | 7 (10.9) |
| Oxygen supplementation required, n (%) | 6 (9.4) | 21 (32.8) | 9 (14.1) | 18 (28.1) | 13 (20.3) | 14 (21.9) |
| Maximum % oxygen supplementation level, range | – | 35-100 | – | 35-100 | 0-60 | 35-100 |
| Maximum L/min oxygen supplementation level, range | 2-4 | 2-60 | 2-4 | 3-60 | 0-4 | 6-60 |
| Patient intubated, n (%) | 0 (0) | 8 (12.5) | 0 (0) | 8 (12.5) | 1 (1.6) | 7 (10.9) |
| Bleeding observed, n (%) | 2 (3.1) | 2 (3.1) | 2 (3.1) | 2 (3.1) | 3 (4.7) | 1 (1.6) |
| Concurrent infections, n (%) | 3 (4.7) | 4 (6.3) | 4 (6.3) | 3 (4.7) | 4 (6.3) | 3 (4.7) |
| Disseminated intravascular coagulation, n (%) | 0 (0) | 3 (4.7) | 0 (0) | 3 (4.7) | 1 (1.6) | 2 (3.1) |
| Pulmonary abnormalities, n (%) | 3 (4.7) | 12 (18.8) | 3 (4.7) | 12 (18.8) | 4 (6.3) | 11 (17.2) |
| Systemic anticytokine therapy given, n (%) | 1 (1.6) | 16 (25.0) | 3 (4.7) | 14 (21.9) | 5 (7.8) | 12 (18.8) |
| Corticosteroids used, n (%) | 1 (1.6) | 11 (17.2) | 2 (3.1) | 10 (15.6) | 4 (6.3) | 8 (12.5) |
| Tocilizumab used, n (%) | 0 (0) | 16 (25.0) | 2 (3.1) | 14 (21.9) | 4 (6.3) | 12 (18.8) |
| 1 dose | 0 (0) | 6 (9.4) | 1 (1.6) | 5 (7.8) | 1 (1.6) | 5 (7.8) |
| 2 doses | 0 (0) | 10 (15.6) | 1 (1.6) | 9 (14.1) | 3 (4.7) | 7 (10.9) |