Predictors of OS in univariate and multivariable analyses
| Variable . | LOT1 . | LOT≥2 . | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis . | Multivariable analysis . | Univariate analysis . | Multivariable analysis . | |||||
| HR . | P . | HR (95% CI) . | P . | HR . | P . | HR (95% CI) . | P . | |
| ECOG PS | ||||||||
| ≤1 vs ≥2 | 1.82 | .0003 | 1.45 (1.032-2.028) | .0320 | 1.76 | <.0001 | 1.85 (1.205-2.827) | .0048 |
| Treatment | ||||||||
| BR or FCR vs other | 0.60 | .0003 | 0.67 (0.482-0.928) | .0162 | 0.70 | .0036 | — | — |
| CCI score | ||||||||
| ≤2 vs ≥3 | 0.49 | <.0001 | 0.58 (0.420-0.803) | .0010 | 0.66 | .0003 | — | — |
| Age category, y | ||||||||
| <75 vs ≥75 | 0.36 | <.0001 | 0.48 (0.345-0.672) | <.0001 | 0.53 | <.0001 | 0.62 (0.408-0.928) | .0205 |
| Site | ||||||||
| Academic vs community/government | 1.03 | NS | — | — | 0.55 | .0097 | 0.34 (0.146-0.770) | .0100 |
| del(17p) | ||||||||
| No vs yes | 0.70 | NS | — | — | 0.40 | <.0001 | 0.47 (0.284-0.781) | .0035 |
| Insurance | ||||||||
| Other vs private | 2.33 | <.0001 | — | — | 1.34 | .0167 | — | — |
| Race | ||||||||
| Other vs white | 1.34 | NS | — | — | 0.99 | NS | — | — |
| Sex | ||||||||
| Female vs male | 1.06 | NS | — | — | 0.78 | .0430 | — | — |
| Region | ||||||||
| South vs West | 1.04 | NS | — | — | NA | NA | — | — |
| Midwest vs West | 0.88 | NS | — | — | NA | NA | — | — |
| Northeast vs West | 0.76 | NS | — | — | NA | NA | — | — |
| CD38 | ||||||||
| Negative vs positive | 0.77 | NS | — | — | 0.87 | NS | — | — |
| Rai stage | ||||||||
| ≤1 vs ≥2 | 0.75 | NS | — | — | 0.88 | NS | — | — |
| Prior malignancy | ||||||||
| No vs yes | 0.70 | .0230 | — | — | 0.81 | NS | — | — |
| Variable . | LOT1 . | LOT≥2 . | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis . | Multivariable analysis . | Univariate analysis . | Multivariable analysis . | |||||
| HR . | P . | HR (95% CI) . | P . | HR . | P . | HR (95% CI) . | P . | |
| ECOG PS | ||||||||
| ≤1 vs ≥2 | 1.82 | .0003 | 1.45 (1.032-2.028) | .0320 | 1.76 | <.0001 | 1.85 (1.205-2.827) | .0048 |
| Treatment | ||||||||
| BR or FCR vs other | 0.60 | .0003 | 0.67 (0.482-0.928) | .0162 | 0.70 | .0036 | — | — |
| CCI score | ||||||||
| ≤2 vs ≥3 | 0.49 | <.0001 | 0.58 (0.420-0.803) | .0010 | 0.66 | .0003 | — | — |
| Age category, y | ||||||||
| <75 vs ≥75 | 0.36 | <.0001 | 0.48 (0.345-0.672) | <.0001 | 0.53 | <.0001 | 0.62 (0.408-0.928) | .0205 |
| Site | ||||||||
| Academic vs community/government | 1.03 | NS | — | — | 0.55 | .0097 | 0.34 (0.146-0.770) | .0100 |
| del(17p) | ||||||||
| No vs yes | 0.70 | NS | — | — | 0.40 | <.0001 | 0.47 (0.284-0.781) | .0035 |
| Insurance | ||||||||
| Other vs private | 2.33 | <.0001 | — | — | 1.34 | .0167 | — | — |
| Race | ||||||||
| Other vs white | 1.34 | NS | — | — | 0.99 | NS | — | — |
| Sex | ||||||||
| Female vs male | 1.06 | NS | — | — | 0.78 | .0430 | — | — |
| Region | ||||||||
| South vs West | 1.04 | NS | — | — | NA | NA | — | — |
| Midwest vs West | 0.88 | NS | — | — | NA | NA | — | — |
| Northeast vs West | 0.76 | NS | — | — | NA | NA | — | — |
| CD38 | ||||||||
| Negative vs positive | 0.77 | NS | — | — | 0.87 | NS | — | — |
| Rai stage | ||||||||
| ≤1 vs ≥2 | 0.75 | NS | — | — | 0.88 | NS | — | — |
| Prior malignancy | ||||||||
| No vs yes | 0.70 | .0230 | — | — | 0.81 | NS | — | — |
NA, not available.