Predictors of EFS in univariate and multivariable analyses
| Variable . | LOT1 . | LOT≥2 . | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis . | Multivariable analysis . | Univariate analysis . | Multivariable analysis . | |||||
| HR . | P . | HR (95% CI) . | P . | HR . | P . | HR (95% CI) . | P . | |
| Age category, y | ||||||||
| <75 vs ≥75 | 0.62 | <.0001 | 0.74 (0.572-0.954) | .0205 | 0.83 | NS | — | — |
| Treatment | ||||||||
| BR or FCR vs other | 0.55 | <.0001 | 0.60 (0.477-0.762) | <.0001 | 0.63 | <.0001 | 0.64 (0.487-0.842) | .0014 |
| del(17p) | ||||||||
| No vs yes | 0.53 | .0002 | 0.54 (0.382-0.757) | .0004 | 0.49 | .0003 | 0.51 (0.345-0.748) | .0006 |
| Insurance | ||||||||
| Other vs private | 1.36 | .0012 | — | — | 0.93 | NS | — | — |
| Race | ||||||||
| Other vs white | 1.34 | .0445 | — | — | 1.01 | NS | — | — |
| ECOG PS | ||||||||
| ≤1 vs ≥2 | 1.05 | NS | — | — | 1.30 | .0160 | — | — |
| Site | ||||||||
| Academic vs community/government | 1.02 | NS | — | — | 0.86 | NS | — | — |
| Sex | ||||||||
| Female vs male | 0.94 | NS | — | — | 0.91 | NS | — | — |
| Rai stage | ||||||||
| ≤1 vs ≥2 | 0.92 | NS | — | — | 0.92 | NS | — | — |
| Prior malignancy | ||||||||
| No vs yes | 0.86 | NS | — | — | 1.00 | NS | — | — |
| CD38 | ||||||||
| Negative vs positive | 0.86 | NS | — | — | 0.77 | .0087 | — | — |
| CCI score | ||||||||
| ≤2 vs ≥3 | 0.80 | .0141 | — | — | 0.85 | NS | — | — |
| Region | ||||||||
| Midwest vs west | 0.80 | NS | — | — | 1.02 | NS | — | — |
| South vs west | 0.78 | NS | — | — | 1.10 | NS | — | — |
| Northeast vs west | 0.78 | NS | — | — | 0.97 | NS | — | — |
| Variable . | LOT1 . | LOT≥2 . | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis . | Multivariable analysis . | Univariate analysis . | Multivariable analysis . | |||||
| HR . | P . | HR (95% CI) . | P . | HR . | P . | HR (95% CI) . | P . | |
| Age category, y | ||||||||
| <75 vs ≥75 | 0.62 | <.0001 | 0.74 (0.572-0.954) | .0205 | 0.83 | NS | — | — |
| Treatment | ||||||||
| BR or FCR vs other | 0.55 | <.0001 | 0.60 (0.477-0.762) | <.0001 | 0.63 | <.0001 | 0.64 (0.487-0.842) | .0014 |
| del(17p) | ||||||||
| No vs yes | 0.53 | .0002 | 0.54 (0.382-0.757) | .0004 | 0.49 | .0003 | 0.51 (0.345-0.748) | .0006 |
| Insurance | ||||||||
| Other vs private | 1.36 | .0012 | — | — | 0.93 | NS | — | — |
| Race | ||||||||
| Other vs white | 1.34 | .0445 | — | — | 1.01 | NS | — | — |
| ECOG PS | ||||||||
| ≤1 vs ≥2 | 1.05 | NS | — | — | 1.30 | .0160 | — | — |
| Site | ||||||||
| Academic vs community/government | 1.02 | NS | — | — | 0.86 | NS | — | — |
| Sex | ||||||||
| Female vs male | 0.94 | NS | — | — | 0.91 | NS | — | — |
| Rai stage | ||||||||
| ≤1 vs ≥2 | 0.92 | NS | — | — | 0.92 | NS | — | — |
| Prior malignancy | ||||||||
| No vs yes | 0.86 | NS | — | — | 1.00 | NS | — | — |
| CD38 | ||||||||
| Negative vs positive | 0.86 | NS | — | — | 0.77 | .0087 | — | — |
| CCI score | ||||||||
| ≤2 vs ≥3 | 0.80 | .0141 | — | — | 0.85 | NS | — | — |
| Region | ||||||||
| Midwest vs west | 0.80 | NS | — | — | 1.02 | NS | — | — |
| South vs west | 0.78 | NS | — | — | 1.10 | NS | — | — |
| Northeast vs west | 0.78 | NS | — | — | 0.97 | NS | — | — |
NS, not significant.