Table 2.

Events graded as NT by CTCAE, but not mCRES and ASTCT

EventNumber of patientsMaximal grade of eventOnset, d from infusion
Headache* 20 1, 1, 1, 2, 2, 2, 2, 3, 3, 4, 5, 5, 6, 7, 8, 9, 18, 28, 63, 195 
Anxiety* 1, 1, 2, 3, 8, 22, 289 
Dizziness* 1, 4, 5, 6, 9, 10, 19, 28 
Insomnia* 4, 6, 8, 18 
Dysphagia* 2, 10 
Syncope 1, 346 
Depression 
Disturbance in attention* 
Dysgeusia* 
Horner’s syndrome* 11 
Hypoesthesia* 138 
Hypotonia 
Mental status changes 323 
Migraine* 
Nerve compression* 279 
Neuralgia* 32 
Paraesthesia* 12 
Peripheral sensory neuropathy* 18 
Polyneuropathy* 
Tearfulness* 
Tremor* 17 
VIth nerve paralysis* 10 
EventNumber of patientsMaximal grade of eventOnset, d from infusion
Headache* 20 1, 1, 1, 2, 2, 2, 2, 3, 3, 4, 5, 5, 6, 7, 8, 9, 18, 28, 63, 195 
Anxiety* 1, 1, 2, 3, 8, 22, 289 
Dizziness* 1, 4, 5, 6, 9, 10, 19, 28 
Insomnia* 4, 6, 8, 18 
Dysphagia* 2, 10 
Syncope 1, 346 
Depression 
Disturbance in attention* 
Dysgeusia* 
Horner’s syndrome* 11 
Hypoesthesia* 138 
Hypotonia 
Mental status changes 323 
Migraine* 
Nerve compression* 279 
Neuralgia* 32 
Paraesthesia* 12 
Peripheral sensory neuropathy* 18 
Polyneuropathy* 
Tearfulness* 
Tremor* 17 
VIth nerve paralysis* 10 
*

Event was observed at least once in a patient with CRS per Penn grade.

Event occurred at least once in a patient with severe (grade 3-4) CRS per Penn grade.

Event occurred twice in same patient.

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