Definition of risk organ involvement in LCH-IV
| Hematopoietic involvement (with or without bone marrow involvement*), at least 2 of the following: |
| Anemia: hemoglobin <100 g/L (<10 g/dl), infants <90 g/L (<9.0 g/dL), not a result of other causes (eg, iron deficiency) |
| Leukocytopenia: leukocytes <4.0 × 109/L (4000/μL) |
| Thrombocytopenia: platelets <100 × 109/L (100 000/μL) |
| Spleen involvement enlargement: |
| >2 cm below costal margin in the midclavicular line† |
| Liver involvement, one or more of the following: |
| Enlargement >3 cm below costal margin in the midclavicular line† |
| Dysfunction (ie, hypoproteinemia <55 g/L, hypoalbuminemia <25 g/L, not as a result of other causes) |
| Histopathological findings of active disease |
| Hematopoietic involvement (with or without bone marrow involvement*), at least 2 of the following: |
| Anemia: hemoglobin <100 g/L (<10 g/dl), infants <90 g/L (<9.0 g/dL), not a result of other causes (eg, iron deficiency) |
| Leukocytopenia: leukocytes <4.0 × 109/L (4000/μL) |
| Thrombocytopenia: platelets <100 × 109/L (100 000/μL) |
| Spleen involvement enlargement: |
| >2 cm below costal margin in the midclavicular line† |
| Liver involvement, one or more of the following: |
| Enlargement >3 cm below costal margin in the midclavicular line† |
| Dysfunction (ie, hypoproteinemia <55 g/L, hypoalbuminemia <25 g/L, not as a result of other causes) |
| Histopathological findings of active disease |