Clinical Classification of LCH
| Clinical group . | Description . |
|---|---|
| Multisystem | Two or more systems involved |
| With risk organ involvement | Involvement of liver, spleen or bone marrow |
| Without risk organ involvement | Without involvement of liver, spleen or bone marrow |
| Single-system | Only 1 system involved |
| Single site | Skin, bone, lymph node, other (thyroid, thymus) |
| Multiple sites | Multifocal bone disease |
| Special site | Skull-base lesion with intracranial extension or vertebral lesion with intraspinal soft tissue extension |
| Pulmonary LCH | Isolated lung disease |
| CNS LCH | Tumorous lesions |
| Neurodegenerative disease | |
| LACI | |
| LACS |
| Clinical group . | Description . |
|---|---|
| Multisystem | Two or more systems involved |
| With risk organ involvement | Involvement of liver, spleen or bone marrow |
| Without risk organ involvement | Without involvement of liver, spleen or bone marrow |
| Single-system | Only 1 system involved |
| Single site | Skin, bone, lymph node, other (thyroid, thymus) |
| Multiple sites | Multifocal bone disease |
| Special site | Skull-base lesion with intracranial extension or vertebral lesion with intraspinal soft tissue extension |
| Pulmonary LCH | Isolated lung disease |
| CNS LCH | Tumorous lesions |
| Neurodegenerative disease | |
| LACI | |
| LACS |