Comparison of LYG with polymorphic PTLD and EBV+ DLBCL
| . | LYG . | Polymorphic PTLD . | EBV+ DLBCL . |
|---|---|---|---|
| Clinical features | Immunodeficient state often unknown | Immunodeficient state known | Often immunocompetent, but immune senescence plays a role |
| Extranodal involvement frequent, most commonly lung, CNS, and skin | Extranodal involvement frequent, most commonly gastrointestinal, lung, CNS, kidney, heart and liver, including the allograft | Extranodal involvement less common and involving diverse sites | |
| Lymph node and/or bone marrow involvement extremely rare | Lymph node involvement uncommon and bone marrow disease rare | Lymph node involvement common and bone marrow disease uncommon | |
| Pathologic features | EBV+ atypical B cells in a T-cell rich background | EBV+ atypical B cells predominate | EBV+ atypical B cells predominate |
| Angiocentric and angioinvasive polymorphous infiltrate present | Polymorphous plasma cell-rich infiltrate present but typically not angiocentric or angioinvasive | EBV+ large B cells predominate | |
| Various degrees of coagulative necrosis | Coagulative necrosis may be present | Various degrees coagulative necrosis | |
| EBV viral load | Often low to negative | Often significantly elevated | Often significantly elevated |
| . | LYG . | Polymorphic PTLD . | EBV+ DLBCL . |
|---|---|---|---|
| Clinical features | Immunodeficient state often unknown | Immunodeficient state known | Often immunocompetent, but immune senescence plays a role |
| Extranodal involvement frequent, most commonly lung, CNS, and skin | Extranodal involvement frequent, most commonly gastrointestinal, lung, CNS, kidney, heart and liver, including the allograft | Extranodal involvement less common and involving diverse sites | |
| Lymph node and/or bone marrow involvement extremely rare | Lymph node involvement uncommon and bone marrow disease rare | Lymph node involvement common and bone marrow disease uncommon | |
| Pathologic features | EBV+ atypical B cells in a T-cell rich background | EBV+ atypical B cells predominate | EBV+ atypical B cells predominate |
| Angiocentric and angioinvasive polymorphous infiltrate present | Polymorphous plasma cell-rich infiltrate present but typically not angiocentric or angioinvasive | EBV+ large B cells predominate | |
| Various degrees of coagulative necrosis | Coagulative necrosis may be present | Various degrees coagulative necrosis | |
| EBV viral load | Often low to negative | Often significantly elevated | Often significantly elevated |