Table 2. LRs for a positive HIPA in... | American Society of Hematology

Table 2.

LRs for a positive HIPA in pooled analysis of retrospective and prospective derivation cohorts

Immunoassay (N = 351)	Result interval	HIT positive	HIT negative	LR	95% CI	100% PV	95% CI
ELISA, OD	0.00 to 0.24	0	258	0.00	0.00‐0.19	Negative	98.6-100
	0.24 to 0.30	1	5	1.26	1.15‐10.56
	0.30 to 1.00	13	30	2.74	1.54‐4.86
	1.00 to 2.00	13	9	9.12	4.12‐20.16
	2.00 to 2.81	16	1*	101.00	13.7‐744.24
	2.81 to 3.50	5	0	∞	3.50‐∞	Positive	36.5-100
PaGIA, titer	0-1	0	271	0.00	0.00‐0.18	Negative	98.7-100
	2	1	21	0.30	0.04‐2.18
	4	6	9	4.21	1.57‐11.29
	8	10	2	31.56	7.13‐139.68
	≥16	31	0	∞	24.34‐∞	Positive	85.0-100
CLIA, U/mL	0.00 to 0.13	0	268	0.00	0.00‐0.19	Negative	98.7-100
	0.13 to 0.33	2	21	0.60	0.15‐2.48
	0.33 to 1.00	7	13	3.40	1.43‐8.09
	1.00 to 3.00	10	1†	63.13	8.27‐482.01
	3.00 to >128	29	0	∞	22.74‐∞	Positive	87.6-100

Immunoassay (N = 351)	Result interval	HIT positive	HIT negative	LR	95% CI	100% PV	95% CI
ELISA, OD	0.00 to 0.24	0	258	0.00	0.00‐0.19	Negative	98.6-100
	0.24 to 0.30	1	5	1.26	1.15‐10.56
	0.30 to 1.00	13	30	2.74	1.54‐4.86
	1.00 to 2.00	13	9	9.12	4.12‐20.16
	2.00 to 2.81	16	1*	101.00	13.7‐744.24
	2.81 to 3.50	5	0	∞	3.50‐∞	Positive	36.5-100
PaGIA, titer	0-1	0	271	0.00	0.00‐0.18	Negative	98.7-100
	2	1	21	0.30	0.04‐2.18
	4	6	9	4.21	1.57‐11.29
	8	10	2	31.56	7.13‐139.68
	≥16	31	0	∞	24.34‐∞	Positive	85.0-100
CLIA, U/mL	0.00 to 0.13	0	268	0.00	0.00‐0.19	Negative	98.7-100
	0.13 to 0.33	2	21	0.60	0.15‐2.48
	0.33 to 1.00	7	13	3.40	1.43‐8.09
	1.00 to 3.00	10	1†	63.13	8.27‐482.01
	3.00 to >128	29	0	∞	22.74‐∞	Positive	87.6-100

N, total number of patients investigated in the retrospective and prospective derivation cohorts; PV, predictive value.

Sample with a result of 2.81 OD.

Sample with a result of 1.27 U/mL.