Multivariable analyses of survival outcomes of AYAs with AML who survived at least 1 year disease free after HCT
| Outcome/variable . | n . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| OS | ||||
| Conditioning regimen | .541 | |||
| Non-TBI MAC | 436 | 1 | ||
| TBI MAC | 390 | 1.10 | 0.82-1.48 | |
| cGVHD | .002 | |||
| No | 371 | 1 | ||
| Yes | 455 | 1.62 | 1.19-2.21 | |
| SN | <.0001 | |||
| No | 810 | 1 | ||
| Yes | 16 | 7.97 | 3.62-17.53 | |
| Relapse | ||||
| Conditioning regimen | .02 | |||
| Non-TBI MAC | 436 | 1 | ||
| TBI MAC | 390 | 0.65 | 0.45-0.94 | |
| NRM | ||||
| Conditioning regimen | .238 | |||
| Non-TBI MAC | 436 | 1 | ||
| TBI MAC | 390 | 1.29 | 0.85-1.97 | |
| cGVHD | <.0001 | |||
| No | 371 | 1 | ||
| Yes | 455 | 3.39 | 2.01-5.72 | |
| Donor | .001 | |||
| HLA-identical sibling | 362 | 1 | ||
| 8/8 MUD | 464 | 2.16 | 1.35-3.45 | |
| SN | <.0001 | |||
| No | 810 | 1 | ||
| Yes | 16 | 14.57 | 5.78-36.75 | |
| LFS | ||||
| Conditioning regimen | .347 | |||
| Non-TBI MAC | 436 | 1 | ||
| TBI MAC | 390 | 0.88 | 0.67-1.15 | |
| cGVHD | .006 | |||
| No | 371 | 1 | ||
| Yes | 455 | 1.47 | 1.11-1.95 | |
| SN | <.0001 | |||
| No | 810 | 1 | ||
| Yes | 16 | 9.09 | 4.12-20.02 |
| Outcome/variable . | n . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| OS | ||||
| Conditioning regimen | .541 | |||
| Non-TBI MAC | 436 | 1 | ||
| TBI MAC | 390 | 1.10 | 0.82-1.48 | |
| cGVHD | .002 | |||
| No | 371 | 1 | ||
| Yes | 455 | 1.62 | 1.19-2.21 | |
| SN | <.0001 | |||
| No | 810 | 1 | ||
| Yes | 16 | 7.97 | 3.62-17.53 | |
| Relapse | ||||
| Conditioning regimen | .02 | |||
| Non-TBI MAC | 436 | 1 | ||
| TBI MAC | 390 | 0.65 | 0.45-0.94 | |
| NRM | ||||
| Conditioning regimen | .238 | |||
| Non-TBI MAC | 436 | 1 | ||
| TBI MAC | 390 | 1.29 | 0.85-1.97 | |
| cGVHD | <.0001 | |||
| No | 371 | 1 | ||
| Yes | 455 | 3.39 | 2.01-5.72 | |
| Donor | .001 | |||
| HLA-identical sibling | 362 | 1 | ||
| 8/8 MUD | 464 | 2.16 | 1.35-3.45 | |
| SN | <.0001 | |||
| No | 810 | 1 | ||
| Yes | 16 | 14.57 | 5.78-36.75 | |
| LFS | ||||
| Conditioning regimen | .347 | |||
| Non-TBI MAC | 436 | 1 | ||
| TBI MAC | 390 | 0.88 | 0.67-1.15 | |
| cGVHD | .006 | |||
| No | 371 | 1 | ||
| Yes | 455 | 1.47 | 1.11-1.95 | |
| SN | <.0001 | |||
| No | 810 | 1 | ||
| Yes | 16 | 9.09 | 4.12-20.02 |
URD, unrelated donor.