Table 3. Correlation of JAK2 V617F and... | American Society of Hematology

Table 3.

Correlation of JAK2^V617F and JAK2 transcript expression levels to HIF target, inflammatory, and coagulation genes in platelets

Gene	Correlation with:
	JAK2^V617F		JAK2 transcript levels
	r	P	r	P
HIF target genes
ADM	0.5488	.0082
BHLHE40			–0.5425	.0075
CDKN1A			0.6067	.0021
CKB	0.4378	.0471	0.5833	.0035
CXCL2	0.6447	.0012
DDIT4			–0.5729	.0043
ENO1			0.6625	.0006
GAPDH			0.6091	.0020
KDR			0.6586	.0006
NFIL3	0.6042	.0029
PLAUR	0.4884	.0211
TEK			0.6942	.0002
TIMP1			0.8378	<.0001
Inflammatory gene
BCL2			–0.4535	.0297
CCL28	−0.4923	.0170
CHI3L1			–0.5119	.0106
CXCL1	0.4426	.0344
IGKC	−0.5322	.0108
MMP9	0.4337	.0437	–0.5553	.0049
PGLYRP1	0.4499	.0312	–0.5586	.0046
PLAU	0.4893	.0178
TNF			–0.6267	.0011
Coagulation genes
ALDOA			0.6753	.0003
ATP1B1	0.5347	.0104	0.6105	.0020
ATP2A3			0.6187	.0013
BSG			0.6532	.0005
CAV1			0.7983	<.0001
CD63			0.6133	.0014
CFL1			0.7678	<.0001
DOCK4	0.4455	.0331
DOCK5			0.4794	.0178
EHD2			0.7901	<.0001
F13B			0.6143	.0014
FCER1G			0.8390	<.0001
GATA1			0.7489	<.0001
GNA15			0.4505	.0272
GNAI2			0.4357	.0333
GNG5	0.5925	.0029
GP1BB			0.7395	<.0001
GP9			0.7901	<.0001
HBE1			0.6971	.0002
HBG2			0.4964	.0136
ITGA2B			0.7519	<.0001
ITGAX	0.5199	.0110
ITGB3			0.7678	<.0001
KCNMB1			0.7445	<.0001
KIF3C			0.7617	<.0001
KIF4A			0.6389	.0008
KIFAP3			0.9091	<.0001
LCP2	0.6407	.0010
MMP1			0.7059	.0001
MRVI1			0.8298	<.0001
P2RX1			0.7452	<.0001
PDE2A			0.8370	<.0001
PIK3R2	0.5299	.0112
PIK3R3			0.8281	<.0001
PLAU	0.4893	.0178
PLAUR	0.4884	.0211
PRKAR1B			0.6883	.0002
PRKCD			0.5719	.0035
PRKG2	0.5898	.0031	0.5284	.0079
PSAP			0.4932	.0143
PTGIR			0.7563	<.0001
SERPINA1	0.5603	.0067
SERPING1	0.3986	.0596	0.4405	.0312
SHC1			0.6179	.0013
SIRPA	0.5049	.0140
SLC16A3	0.4563	.0328
SLC7A11			0.6874	.0002
SOS1			0.8916	<.0001
TEK			0.6790	.0003
TGFB1			0.5578	.0046
TIMP1			0.8465	<.0001
TREM1	0.5070	.0160
VEGFC			0.8644	<.0001
ZFPM2			0.8947	<.0001

Gene	Correlation with:
	JAK2^V617F		JAK2 transcript levels
	r	P	r	P
HIF target genes
ADM	0.5488	.0082
BHLHE40			–0.5425	.0075
CDKN1A			0.6067	.0021
CKB	0.4378	.0471	0.5833	.0035
CXCL2	0.6447	.0012
DDIT4			–0.5729	.0043
ENO1			0.6625	.0006
GAPDH			0.6091	.0020
KDR			0.6586	.0006
NFIL3	0.6042	.0029
PLAUR	0.4884	.0211
TEK			0.6942	.0002
TIMP1			0.8378	<.0001
Inflammatory gene
BCL2			–0.4535	.0297
CCL28	−0.4923	.0170
CHI3L1			–0.5119	.0106
CXCL1	0.4426	.0344
IGKC	−0.5322	.0108
MMP9	0.4337	.0437	–0.5553	.0049
PGLYRP1	0.4499	.0312	–0.5586	.0046
PLAU	0.4893	.0178
TNF			–0.6267	.0011
Coagulation genes
ALDOA			0.6753	.0003
ATP1B1	0.5347	.0104	0.6105	.0020
ATP2A3			0.6187	.0013
BSG			0.6532	.0005
CAV1			0.7983	<.0001
CD63			0.6133	.0014
CFL1			0.7678	<.0001
DOCK4	0.4455	.0331
DOCK5			0.4794	.0178
EHD2			0.7901	<.0001
F13B			0.6143	.0014
FCER1G			0.8390	<.0001
GATA1			0.7489	<.0001
GNA15			0.4505	.0272
GNAI2			0.4357	.0333
GNG5	0.5925	.0029
GP1BB			0.7395	<.0001
GP9			0.7901	<.0001
HBE1			0.6971	.0002
HBG2			0.4964	.0136
ITGA2B			0.7519	<.0001
ITGAX	0.5199	.0110
ITGB3			0.7678	<.0001
KCNMB1			0.7445	<.0001
KIF3C			0.7617	<.0001
KIF4A			0.6389	.0008
KIFAP3			0.9091	<.0001
LCP2	0.6407	.0010
MMP1			0.7059	.0001
MRVI1			0.8298	<.0001
P2RX1			0.7452	<.0001
PDE2A			0.8370	<.0001
PIK3R2	0.5299	.0112
PIK3R3			0.8281	<.0001
PLAU	0.4893	.0178
PLAUR	0.4884	.0211
PRKAR1B			0.6883	.0002
PRKCD			0.5719	.0035
PRKG2	0.5898	.0031	0.5284	.0079
PSAP			0.4932	.0143
PTGIR			0.7563	<.0001
SERPINA1	0.5603	.0067
SERPING1	0.3986	.0596	0.4405	.0312
SHC1			0.6179	.0013
SIRPA	0.5049	.0140
SLC16A3	0.4563	.0328
SLC7A11			0.6874	.0002
SOS1			0.8916	<.0001
TEK			0.6790	.0003
TGFB1			0.5578	.0046
TIMP1			0.8465	<.0001
TREM1	0.5070	.0160
VEGFC			0.8644	<.0001
ZFPM2			0.8947	<.0001

View Large

This Feature Is Available To Subscribers Only