Correlation of JAK2V617F and JAK2 transcript expression levels with HIF target, inflammatory, and coagulation genes in granulocytes
| Gene . | Correlation with: . | |||
|---|---|---|---|---|
| JAK2V617F . | JAK2 transcript levels . | |||
| r . | P . | r . | P . | |
| HIF target genes | ||||
| CDKN1A | 0.4677 | .0282 | 0.5067 | .0161 |
| CXCL2 | 0.5705 | .0056 | 0.5348 | .0103 |
| EGLN3 | −0.4550 | .0382 | ||
| FHL1 | −0.6081 | .0027 | −0.5111 | .0151 |
| LDHA | 0.5357 | .0102 | 0.6786 | .0005 |
| NBN | 0.4272 | .0474 | ||
| NDRG1 | 0.6020 | .0030 | 0.5056 | .0164 |
| PKM | 0.5017 | .0174 | ||
| SLC2A1 | 0.6950 | .0003 | 0.6509 | .0010 |
| TNFSF15 | 0.5105 | .0181 | ||
| VEGFA | 0.4947 | .0192 | ||
| Inflammatory genes | ||||
| CXCL3 | 0.5861 | .0042 | 0.6316 | .0016 |
| F3 | 0.5081 | .0158 | 0.5640 | .0063 |
| HAMP | 0.5660 | .0060 | ||
| IGHG1 | −0.4737 | .0301 | −0.5388 | .0117 |
| IL10 | 0.5618 | .0065 | 0.6825 | .0005 |
| MMP9 | 0.6270 | .0023 | ||
| PTX3 | 0.4760 | .0339 | ||
| TNFRSF4 | −0.7270 | .0001 | −0.6069 | .0027 |
| Coagulation genes | ||||
| ANGPT1 | −0.5688 | .0057 | −0.4978 | .0216 |
| APP | 0.4263 | .0479 | ||
| CDK2 | 0.5665 | .0060 | 0.5898 | .0039 |
| CLU | −0.4887 | .0210 | −0.4739 | .0259 |
| EGF | −0.5395 | .0096 | −0.4684 | .0279 |
| F13A1 | −0.4607 | .0310 | ||
| F3 | 0.5081 | .0158 | 0.5640 | .0063 |
| F5 | 0.6487 | .0011 | 0.6751 | .0006 |
| F8 | 0.4598 | .0313 | 0.5052 | .0165 |
| FCER1G | 0.7437 | < .0001 | 0.7241 | .0001 |
| GATA2 | −0.5093 | .0184 | ||
| GNA15 | 0.6367 | .0014 | 0.5071 | .0160 |
| GNG5 | 0.5788 | .0048 | 0.7451 | < .0001 |
| GP1BA | −0.5750 | .0051 | ||
| GUCY1A3 | −0.5177 | .0136 | −0.4815 | .0233 |
| ITGA2B | −0.4914 | .0202 | −0.4977 | .0184 |
| ITGB3 | −0.5069 | .0161 | −0.4782 | .0244 |
| KIF15 | 0.6476 | .0011 | 0.7440 | < .0001 |
| MAPK14 | 0.6371 | .0014 | 0.5782 | .0048 |
| MERTK | 0.7959 | < .0001 | 0.8446 | < .0001 |
| MGLL | −0.5061 | .0192 | ||
| MMRN1 | −0.4321 | .0446 | ||
| NFE2 | 0.7565 | < .0001 | 0.8320 | < .0001 |
| PDE1B | 0.5020 | .0173 | ||
| PTK2 | −0.5562 | .0072 | −0.4388 | .0410 |
| SERPINB2 | −0.4330 | .0441 | −0.4723 | .0265 |
| SLC7A11 | 0.7042 | .0003 | 0.5832 | .0044 |
| SPARC | −0.6651 | .0007 | −0.5110 | .0151 |
| TFPI | −0.5057 | .0164 | ||
| THBD | 0.6760 | .0006 | 0.6175 | .0022 |
| VEGFA | 0.4947 | .0192 | ||
| Gene . | Correlation with: . | |||
|---|---|---|---|---|
| JAK2V617F . | JAK2 transcript levels . | |||
| r . | P . | r . | P . | |
| HIF target genes | ||||
| CDKN1A | 0.4677 | .0282 | 0.5067 | .0161 |
| CXCL2 | 0.5705 | .0056 | 0.5348 | .0103 |
| EGLN3 | −0.4550 | .0382 | ||
| FHL1 | −0.6081 | .0027 | −0.5111 | .0151 |
| LDHA | 0.5357 | .0102 | 0.6786 | .0005 |
| NBN | 0.4272 | .0474 | ||
| NDRG1 | 0.6020 | .0030 | 0.5056 | .0164 |
| PKM | 0.5017 | .0174 | ||
| SLC2A1 | 0.6950 | .0003 | 0.6509 | .0010 |
| TNFSF15 | 0.5105 | .0181 | ||
| VEGFA | 0.4947 | .0192 | ||
| Inflammatory genes | ||||
| CXCL3 | 0.5861 | .0042 | 0.6316 | .0016 |
| F3 | 0.5081 | .0158 | 0.5640 | .0063 |
| HAMP | 0.5660 | .0060 | ||
| IGHG1 | −0.4737 | .0301 | −0.5388 | .0117 |
| IL10 | 0.5618 | .0065 | 0.6825 | .0005 |
| MMP9 | 0.6270 | .0023 | ||
| PTX3 | 0.4760 | .0339 | ||
| TNFRSF4 | −0.7270 | .0001 | −0.6069 | .0027 |
| Coagulation genes | ||||
| ANGPT1 | −0.5688 | .0057 | −0.4978 | .0216 |
| APP | 0.4263 | .0479 | ||
| CDK2 | 0.5665 | .0060 | 0.5898 | .0039 |
| CLU | −0.4887 | .0210 | −0.4739 | .0259 |
| EGF | −0.5395 | .0096 | −0.4684 | .0279 |
| F13A1 | −0.4607 | .0310 | ||
| F3 | 0.5081 | .0158 | 0.5640 | .0063 |
| F5 | 0.6487 | .0011 | 0.6751 | .0006 |
| F8 | 0.4598 | .0313 | 0.5052 | .0165 |
| FCER1G | 0.7437 | < .0001 | 0.7241 | .0001 |
| GATA2 | −0.5093 | .0184 | ||
| GNA15 | 0.6367 | .0014 | 0.5071 | .0160 |
| GNG5 | 0.5788 | .0048 | 0.7451 | < .0001 |
| GP1BA | −0.5750 | .0051 | ||
| GUCY1A3 | −0.5177 | .0136 | −0.4815 | .0233 |
| ITGA2B | −0.4914 | .0202 | −0.4977 | .0184 |
| ITGB3 | −0.5069 | .0161 | −0.4782 | .0244 |
| KIF15 | 0.6476 | .0011 | 0.7440 | < .0001 |
| MAPK14 | 0.6371 | .0014 | 0.5782 | .0048 |
| MERTK | 0.7959 | < .0001 | 0.8446 | < .0001 |
| MGLL | −0.5061 | .0192 | ||
| MMRN1 | −0.4321 | .0446 | ||
| NFE2 | 0.7565 | < .0001 | 0.8320 | < .0001 |
| PDE1B | 0.5020 | .0173 | ||
| PTK2 | −0.5562 | .0072 | −0.4388 | .0410 |
| SERPINB2 | −0.4330 | .0441 | −0.4723 | .0265 |
| SLC7A11 | 0.7042 | .0003 | 0.5832 | .0044 |
| SPARC | −0.6651 | .0007 | −0.5110 | .0151 |
| TFPI | −0.5057 | .0164 | ||
| THBD | 0.6760 | .0006 | 0.6175 | .0022 |
| VEGFA | 0.4947 | .0192 | ||