OS (median in years, and 3-year percentage) by age, sex, genetic, and clinical subgroup
| Patients and comparison . | <60 y . | 60-74 y . | <60 vs 60-74 y . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n . | Median OS, y . | 3-year OS, % . | P . | HR (95% CI) . | n . | Median OS, y . | 3-year OS, % . | P . | HR (95% CI) . | P . | HR (95% CI) . | |
| All | ||||||||||||
| FLT3-ITD | 194 | 1.87 | 45.1 | .00008 | 1.60 (1.26-2.02) | 193 | 1.33 | 34.8 | .50226 | 1.07 (0.88-1.30) | .00083 | 1.54 (1.10-1.99) |
| No FLT3-ITD | 515 | >8 | 63.4 | 1 | 654 | 1.49 | 35.5 | 1 | 0 | 2.32 (1.96-2.74) | ||
| Males | ||||||||||||
| FLT3-ITD | 95 | 2.55 | 50.0 | .0194 | 1.49 (1.06-2.09) | 90 | 1.4 | 35.4 | .91331 | 0.99 (0.75-1.29) | .0099 | 1.63 (1.12-2.37) |
| No FLT3-ITD | 287 | >8 | 65.2 | 1 | 380 | 1.45 | 33.5 | 1 | 0 | 2.48 (1.99-3.10) | ||
| Females | ||||||||||||
| FLT3-ITD | 99 | 1.72 | 40.8 | .0012 | 1.71 (1.23-2.38) | 103 | 1.13 | 34.3 | .25597 | 1.17 (0.89-1.55) | .0344 | 1.46 (1.03-2.06) |
| No FLT3-ITD | 228 | >5 | 61.1 | 1 | 274 | 1.64 | 38.4 | 1 | 0 | 2.10 (1.63-2.70) | ||
| De novo/intensive Tx | ||||||||||||
| FLT3-ITD | 176 | 2.23 | 48.2 | .00005 | 1.70 (1.31-2.19) | 155 | 1.6 | 39.5 | .19051 | 1.16 (0.93-1.46) | .0033 | 1.52 (1.15-2.02) |
| No FLT3-ITD | 454 | >12 | 66.9 | 1 | 455 | 2.16 | 42.8 | 1 | 0 | 2.24 (1.84-2.71) | ||
| All | ||||||||||||
| NPM1 mut | 198 | 11.83 | 59.4 | .5428 | 0.92 (0.72-1.19) | 258 | 2.92 | 49.8 | 0 | 0.64 (0.53-0.78) | .00038 | 1.63 (1.24-2.14) |
| NPM1 wt | 473 | 7.53 | 58.3 | 1 | 546 | 1.24 | 28.9 | 1 | 0 | 2.33 (1.97-2.76) | ||
| Males | ||||||||||||
| NPM1 mut | 92 | >12 | 68.2 | .1126 | 0.73 (0.49-1.08) | 124 | 3.01 | 50.6 | .00086 | 0.64 (0.49-0.83) | .00061 | 2.07 (1.35-3.17) |
| NPM1 wt | 270 | 7.53 | 58.4 | 1 | 322 | 1.28 | 28.4 | 1 | 0 | 2.29 (1.83-2.85) | ||
| Females | ||||||||||||
| NPM1 mut | 106 | 5.02 | 52.3 | .5158 | 1.12 (0.80-1.58) | 134 | 2.92 | 49.0 | .00233 | 0.65 (0.50-0.86) | .095 | 1.35 (0.95-1.94) |
| NPM1 wt | 203 | 7.47 | 58.1 | 1 | 224 | 1.23 | 29.8 | 1 | 0 | 2.36 (1.82-3.07) | ||
| De novo/intensive Tx | ||||||||||||
| NPM1 mut | 175 | 11.83 | 62.2 | .5643 | 0.92 (0.69-1.22) | 210 | 3.01 | 50.5 | .01514 | 0.76 (0.61-0.95) | .00012 | 1.80 (1.33-2.43) |
| NPM1 wt | 420 | >8 | 61.7 | 1 | 367 | 1.7 | 36.8 | 1 | 0 | 2.16 (1.78-2.63) | ||
| All | ||||||||||||
| FLT3-ITD/NPM1 mut | 95 | 1.93 | 46.1 | .00035 | 1.45 (1.05-1.99) | 109 | 1.99 | 46.7 | .00002 | 0.76 (0.59-0.99) | .1401 | 1.32 (0.91-1.91) |
| FLT3-ITD/NPM1 wt | 83 | 2.06 | 44.3 | 1.56 (1.13-2.17) | 69 | 0.96 | 18.9 | 1.25 (0.94-1.66) | .00029 | 2.03 (1.37-3.00) | ||
| No FLT3-ITD/NPM1 mut | 100 | >12 | 71.5 | 0.69 (0.48-1.01) | 144 | 3.3 | 51.5 | 0.59 (0.46-0.76) | .00025 | 2.13 (1.41-3.23) | ||
| Double negative | 386 | 10.06 | 61.5 | 1 | 475 | 1.28 | 30.6 | 1 | 0 | 2.45 (2.03-2.97) | ||
| De novo/intensive Tx | ||||||||||||
| FLT3-ITD/NPM1 mut | 81 | 11.83 | 52.0 | .0002 | 1.44 (0.99-2.07) | 93 | 2.38 | 48.8 | 0.01237 | 0.90 (0.67-1.20) | .0515 | 1.51 (0.99-2.30) |
| FLT3-ITD/NPM1 wt | 80 | 2.06 | 44.7 | 1.85 (1.32-2.61) | 51 | 1.21 | 24.2 | 1.40 (0.99-1.97) | .0059 | 1.82 (1.18-2.79) | ||
| no FLT3-ITD/NPM1 mut | 92 | >12 | 71.3 | 0.77 (0.51-1.15) | 114 | 3.3 | 52.0 | 0.73 (0.54-0.97) | .00027 | 2.26 (1.44-3.54) | ||
| Double negative | 337 | >10 | 66.0 | 1 | 314 | 1.85 | 39.1 | 1 | 0 | 2.36 (1.88-2.95) | ||
| Patients and comparison . | <60 y . | 60-74 y . | <60 vs 60-74 y . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n . | Median OS, y . | 3-year OS, % . | P . | HR (95% CI) . | n . | Median OS, y . | 3-year OS, % . | P . | HR (95% CI) . | P . | HR (95% CI) . | |
| All | ||||||||||||
| FLT3-ITD | 194 | 1.87 | 45.1 | .00008 | 1.60 (1.26-2.02) | 193 | 1.33 | 34.8 | .50226 | 1.07 (0.88-1.30) | .00083 | 1.54 (1.10-1.99) |
| No FLT3-ITD | 515 | >8 | 63.4 | 1 | 654 | 1.49 | 35.5 | 1 | 0 | 2.32 (1.96-2.74) | ||
| Males | ||||||||||||
| FLT3-ITD | 95 | 2.55 | 50.0 | .0194 | 1.49 (1.06-2.09) | 90 | 1.4 | 35.4 | .91331 | 0.99 (0.75-1.29) | .0099 | 1.63 (1.12-2.37) |
| No FLT3-ITD | 287 | >8 | 65.2 | 1 | 380 | 1.45 | 33.5 | 1 | 0 | 2.48 (1.99-3.10) | ||
| Females | ||||||||||||
| FLT3-ITD | 99 | 1.72 | 40.8 | .0012 | 1.71 (1.23-2.38) | 103 | 1.13 | 34.3 | .25597 | 1.17 (0.89-1.55) | .0344 | 1.46 (1.03-2.06) |
| No FLT3-ITD | 228 | >5 | 61.1 | 1 | 274 | 1.64 | 38.4 | 1 | 0 | 2.10 (1.63-2.70) | ||
| De novo/intensive Tx | ||||||||||||
| FLT3-ITD | 176 | 2.23 | 48.2 | .00005 | 1.70 (1.31-2.19) | 155 | 1.6 | 39.5 | .19051 | 1.16 (0.93-1.46) | .0033 | 1.52 (1.15-2.02) |
| No FLT3-ITD | 454 | >12 | 66.9 | 1 | 455 | 2.16 | 42.8 | 1 | 0 | 2.24 (1.84-2.71) | ||
| All | ||||||||||||
| NPM1 mut | 198 | 11.83 | 59.4 | .5428 | 0.92 (0.72-1.19) | 258 | 2.92 | 49.8 | 0 | 0.64 (0.53-0.78) | .00038 | 1.63 (1.24-2.14) |
| NPM1 wt | 473 | 7.53 | 58.3 | 1 | 546 | 1.24 | 28.9 | 1 | 0 | 2.33 (1.97-2.76) | ||
| Males | ||||||||||||
| NPM1 mut | 92 | >12 | 68.2 | .1126 | 0.73 (0.49-1.08) | 124 | 3.01 | 50.6 | .00086 | 0.64 (0.49-0.83) | .00061 | 2.07 (1.35-3.17) |
| NPM1 wt | 270 | 7.53 | 58.4 | 1 | 322 | 1.28 | 28.4 | 1 | 0 | 2.29 (1.83-2.85) | ||
| Females | ||||||||||||
| NPM1 mut | 106 | 5.02 | 52.3 | .5158 | 1.12 (0.80-1.58) | 134 | 2.92 | 49.0 | .00233 | 0.65 (0.50-0.86) | .095 | 1.35 (0.95-1.94) |
| NPM1 wt | 203 | 7.47 | 58.1 | 1 | 224 | 1.23 | 29.8 | 1 | 0 | 2.36 (1.82-3.07) | ||
| De novo/intensive Tx | ||||||||||||
| NPM1 mut | 175 | 11.83 | 62.2 | .5643 | 0.92 (0.69-1.22) | 210 | 3.01 | 50.5 | .01514 | 0.76 (0.61-0.95) | .00012 | 1.80 (1.33-2.43) |
| NPM1 wt | 420 | >8 | 61.7 | 1 | 367 | 1.7 | 36.8 | 1 | 0 | 2.16 (1.78-2.63) | ||
| All | ||||||||||||
| FLT3-ITD/NPM1 mut | 95 | 1.93 | 46.1 | .00035 | 1.45 (1.05-1.99) | 109 | 1.99 | 46.7 | .00002 | 0.76 (0.59-0.99) | .1401 | 1.32 (0.91-1.91) |
| FLT3-ITD/NPM1 wt | 83 | 2.06 | 44.3 | 1.56 (1.13-2.17) | 69 | 0.96 | 18.9 | 1.25 (0.94-1.66) | .00029 | 2.03 (1.37-3.00) | ||
| No FLT3-ITD/NPM1 mut | 100 | >12 | 71.5 | 0.69 (0.48-1.01) | 144 | 3.3 | 51.5 | 0.59 (0.46-0.76) | .00025 | 2.13 (1.41-3.23) | ||
| Double negative | 386 | 10.06 | 61.5 | 1 | 475 | 1.28 | 30.6 | 1 | 0 | 2.45 (2.03-2.97) | ||
| De novo/intensive Tx | ||||||||||||
| FLT3-ITD/NPM1 mut | 81 | 11.83 | 52.0 | .0002 | 1.44 (0.99-2.07) | 93 | 2.38 | 48.8 | 0.01237 | 0.90 (0.67-1.20) | .0515 | 1.51 (0.99-2.30) |
| FLT3-ITD/NPM1 wt | 80 | 2.06 | 44.7 | 1.85 (1.32-2.61) | 51 | 1.21 | 24.2 | 1.40 (0.99-1.97) | .0059 | 1.82 (1.18-2.79) | ||
| no FLT3-ITD/NPM1 mut | 92 | >12 | 71.3 | 0.77 (0.51-1.15) | 114 | 3.3 | 52.0 | 0.73 (0.54-0.97) | .00027 | 2.26 (1.44-3.54) | ||
| Double negative | 337 | >10 | 66.0 | 1 | 314 | 1.85 | 39.1 | 1 | 0 | 2.36 (1.88-2.95) | ||
P values and hazard ratios calculated with R statistics comparing OS by genetic subset within each patient selection, and in the far-right column by age group within a genetic subset.