Number of unique subclones that have a different codon sequence at the location of the N-gly site to that of the major clone
| Patient . | Disease event . | No. of unique tumor-related subclones . | No of unique tumor subclones with different codon sequence in N-gly site region to the MC (% of total subclones) . | Subclones with different codon sequence in N-gly region . | |
|---|---|---|---|---|---|
| Percentage of subclones without N-gly site . | Percentage of subclones with N-gly site . | ||||
| 1 | Diagnosis | 2727 | 107 (3.92) | 1.69 | 2.24 |
| Transformation | 1690 | 110 (6.51) | 1.83 | 4.67 | |
| 2 | First relapse | 3530 | 96 (2.72), 113 (3.20), 2062 (58.41), 226 (6.40) | 0.99, 0.99, 1.13, 2.78 | 1.73, 2.21, 57.28, 3.63 |
| Third relapse | 3032 | 145 (4.78), 239 (7.88), 982 (32.39), 737 (24.31) | 0.69, 3.10, 1.25, 18.17 | 4.09, 4.68, 31.13, 6.13 | |
| Transformation | 3966 | 134 (3.38), 148 (3.73), 1370 (34.54), 747 (18.84) | 1.46, 1.84, 2.29, 15.05 | 1.92, 1.89, 32.25, 3.78 | |
| 3 | Second relapse | 4103 | 385 (9.38) | 2.53 | 6.85 |
| Third relapse | 2057 | 179 (8.70) | 2.09 | 6.61 | |
| Transformation | 1592 | 455 (28.58) | 1.82 | 26.76 | |
| 4 | First relapse | 81 | 28 (34.57), 0 | 2.47, 0 | 32.1, 0 |
| Second relapse | 248 | 14 (5.65), 1 (0.40) | 2.02, 0.40 | 3.63, 0 | |
| 5 | First relapse | 140 | 22 (15.71) | 2.86 | 12.86 |
| Third relapse | 371 | 21 (5.66) | 0.81 | 4.85 | |
| 6 | FL diagnosis | 2510 | 946 (37.69) | 1.59 | 36.10 |
| tFL diagnosis | 3442 | 265 (7.70) | 2.06 | 5.64 | |
| tFL relapse | 4749 | 214 (4.51) | 2.70 | 1.81 | |
| Patient . | Disease event . | No. of unique tumor-related subclones . | No of unique tumor subclones with different codon sequence in N-gly site region to the MC (% of total subclones) . | Subclones with different codon sequence in N-gly region . | |
|---|---|---|---|---|---|
| Percentage of subclones without N-gly site . | Percentage of subclones with N-gly site . | ||||
| 1 | Diagnosis | 2727 | 107 (3.92) | 1.69 | 2.24 |
| Transformation | 1690 | 110 (6.51) | 1.83 | 4.67 | |
| 2 | First relapse | 3530 | 96 (2.72), 113 (3.20), 2062 (58.41), 226 (6.40) | 0.99, 0.99, 1.13, 2.78 | 1.73, 2.21, 57.28, 3.63 |
| Third relapse | 3032 | 145 (4.78), 239 (7.88), 982 (32.39), 737 (24.31) | 0.69, 3.10, 1.25, 18.17 | 4.09, 4.68, 31.13, 6.13 | |
| Transformation | 3966 | 134 (3.38), 148 (3.73), 1370 (34.54), 747 (18.84) | 1.46, 1.84, 2.29, 15.05 | 1.92, 1.89, 32.25, 3.78 | |
| 3 | Second relapse | 4103 | 385 (9.38) | 2.53 | 6.85 |
| Third relapse | 2057 | 179 (8.70) | 2.09 | 6.61 | |
| Transformation | 1592 | 455 (28.58) | 1.82 | 26.76 | |
| 4 | First relapse | 81 | 28 (34.57), 0 | 2.47, 0 | 32.1, 0 |
| Second relapse | 248 | 14 (5.65), 1 (0.40) | 2.02, 0.40 | 3.63, 0 | |
| 5 | First relapse | 140 | 22 (15.71) | 2.86 | 12.86 |
| Third relapse | 371 | 21 (5.66) | 0.81 | 4.85 | |
| 6 | FL diagnosis | 2510 | 946 (37.69) | 1.59 | 36.10 |
| tFL diagnosis | 3442 | 265 (7.70) | 2.06 | 5.64 | |
| tFL relapse | 4749 | 214 (4.51) | 2.70 | 1.81 | |
The percentage of these subclones that are either motif positive or motif negative are provided. Percentages were calculated from the total number of unique subclones identified. Values were rounded to 2 decimal points.