Characteristics of 88 patients studied in cohort
| Total patients . | N = 88 . |
|---|---|
| Median age (range), y | 54 (18-81) |
| Median age, n (%), y | |
| <40 | 23 (26) |
| 40-59 | 33 (38) |
| >60 | 32 (36) |
| Sex, n (%) | |
| Female | 40 (45) |
| Male | 48 (55) |
| Self-reported ethnicity, n (%) | |
| White or Caucasian | 68 (77) |
| Hispanic or Latino | 5 (6) |
| Asian | 5 (6) |
| Black or African American | 2 (2) |
| South Asian/Indian | 1 (1) |
| Unknown/not reported | 7 (8) |
| Precipitating etiology, n (%) | |
| Malignancy | 43 (49) |
| Infection | 26 (30) |
| Autoimmune disease | 15 (17) |
| Multiple | 14 (16) |
| Idiopathic | 20 (23) |
| HLH-04 criteria, n (%) | |
| 5* | 26 (30) |
| 6 | 38 (43) |
| 7 | 21 (24) |
| 8 | 3 (3) |
| Total patients . | N = 88 . |
|---|---|
| Median age (range), y | 54 (18-81) |
| Median age, n (%), y | |
| <40 | 23 (26) |
| 40-59 | 33 (38) |
| >60 | 32 (36) |
| Sex, n (%) | |
| Female | 40 (45) |
| Male | 48 (55) |
| Self-reported ethnicity, n (%) | |
| White or Caucasian | 68 (77) |
| Hispanic or Latino | 5 (6) |
| Asian | 5 (6) |
| Black or African American | 2 (2) |
| South Asian/Indian | 1 (1) |
| Unknown/not reported | 7 (8) |
| Precipitating etiology, n (%) | |
| Malignancy | 43 (49) |
| Infection | 26 (30) |
| Autoimmune disease | 15 (17) |
| Multiple | 14 (16) |
| Idiopathic | 20 (23) |
| HLH-04 criteria, n (%) | |
| 5* | 26 (30) |
| 6 | 38 (43) |
| 7 | 21 (24) |
| 8 | 3 (3) |
Three patients were determined to meet at least 5 HLH-04 criteria by the treating clinician but had 4 documented criteria in the clinical database due to incomplete information (see “Methods” and supplemental Figure 1A).