Table 1. Risk stratification for... | American Society of Hematology

Table 1.

Risk stratification for thrombolysis

Contraindications as provided in European Society of Cardiology guidelines⁴	Contraindications as provided in ACCP guidelines³	Peripheral vascular disease, elderly, prior CVA, and prior heart attack score¹³
Absolute contraindications History of hemorrhagic stroke or stroke of unknown origin Ischemic stroke in previous 6 mo Central nervous system neoplasm Major trauma, surgery, or head injury in previous 3 wk Bleeding diathesis Active bleeding	Major contraindications Previous intracranial hemorrhage Ischemic stroke within 3 mo Structural intracranial disease Recent head trauma with fracture or brain injury; recent brain or spinal surgery Bleeding diathesis Active bleeding	Preexisting peripheral vascular disease (1 point) Age >65 y (1 point) Prior CVA with residual deficit (5 points) Prior myocardial infarction (1 point)
Relative contraindications Transient ischemic attack in previous 6 mo Oral anticoagulation Pregnancy or first postpartum week Noncompressible puncture sites Traumatic resuscitation Refractory hypertension (systolic blood pressure [BP] > 180 mmHg) Advanced liver disease Infective endocarditis Active peptic ulcer	Relative contraindications Ischemic stroke >3 mo previously Anticoagulated Pregnancy Traumatic cardiopulmonary resuscitation Systolic BP > 180 mmHg or diastolic BP > 110 mmHg Pericarditis or pericardial fluid Diabetic retinopathy Recent bleeding (nonintracranial) or invasive procedure/surgery Low body weight (<60 kg) Age >75 y Female Black race

Contraindications as provided in European Society of Cardiology guidelines⁴	Contraindications as provided in ACCP guidelines³	Peripheral vascular disease, elderly, prior CVA, and prior heart attack score¹³
Absolute contraindications History of hemorrhagic stroke or stroke of unknown origin Ischemic stroke in previous 6 mo Central nervous system neoplasm Major trauma, surgery, or head injury in previous 3 wk Bleeding diathesis Active bleeding	Major contraindications Previous intracranial hemorrhage Ischemic stroke within 3 mo Structural intracranial disease Recent head trauma with fracture or brain injury; recent brain or spinal surgery Bleeding diathesis Active bleeding	Preexisting peripheral vascular disease (1 point) Age >65 y (1 point) Prior CVA with residual deficit (5 points) Prior myocardial infarction (1 point)
Relative contraindications Transient ischemic attack in previous 6 mo Oral anticoagulation Pregnancy or first postpartum week Noncompressible puncture sites Traumatic resuscitation Refractory hypertension (systolic blood pressure [BP] > 180 mmHg) Advanced liver disease Infective endocarditis Active peptic ulcer	Relative contraindications Ischemic stroke >3 mo previously Anticoagulated Pregnancy Traumatic cardiopulmonary resuscitation Systolic BP > 180 mmHg or diastolic BP > 110 mmHg Pericarditis or pericardial fluid Diabetic retinopathy Recent bleeding (nonintracranial) or invasive procedure/surgery Low body weight (<60 kg) Age >75 y Female Black race

ACCP, American College of Chest Physicians.