Table 2.

PFS at 3 years according to PET2 status and age (ITT population)

A+AVD, % (95% CI), n = 664ABVD, % (95% CI), n = 670Difference, %HR (95% CI)*P†
All patients 83.1 (79.9-85.9) 76.0 (72.4-79.2) 7.1 0.70 (0.55-0.90) .005 
 PET2− 85.8 (82.6-88.5), n = 577 79.5 (75.8-82.7), n = 573 6.3 0.69 (0.52-0.91) .009 
 PET2+ 67.7 (53.8-78.3), n = 58 51.5 (38.2-63.4), n = 63 16.2 0.59 (0.33-1.07) .077 
Age and PET2 status      
 <60 y 84.9 (81.6-87.7), n = 580 77.8 (73.9-81.1), n = 568 7.1 0.69 (0.52-0.91) .008 
  PET2− 87.2 (83.9-89.9), n = 512 81.0 (77.1-84.4), n = 489 6.2 0.71 (0.51-0.98) .034 
  PET2+ 69.2 (54.1-80.1), n = 51 54.7 (40.0-67.2), n = 54 14.5 0.60 (0.32-1.15) .117 
 ≥60 y 70.5 (58.6-79.5), n = 84 66.5 (55.9-75.2), n = 102 4.0 0.79 (0.46-1.33) .366 
  PET2− 75.2 (62.1-84.3), n = 65 70.9 (59.8-79.5), n = 84 4.3 0.70 (0.38-1.30) .258 
  PET2+ 57.1 (17.2-83.7), n = 7 33.3 (7.8-62.3), n = 9 23.8 0.65 (0.16-2.63) .545 
A+AVD, % (95% CI), n = 664ABVD, % (95% CI), n = 670Difference, %HR (95% CI)*P†
All patients 83.1 (79.9-85.9) 76.0 (72.4-79.2) 7.1 0.70 (0.55-0.90) .005 
 PET2− 85.8 (82.6-88.5), n = 577 79.5 (75.8-82.7), n = 573 6.3 0.69 (0.52-0.91) .009 
 PET2+ 67.7 (53.8-78.3), n = 58 51.5 (38.2-63.4), n = 63 16.2 0.59 (0.33-1.07) .077 
Age and PET2 status      
 <60 y 84.9 (81.6-87.7), n = 580 77.8 (73.9-81.1), n = 568 7.1 0.69 (0.52-0.91) .008 
  PET2− 87.2 (83.9-89.9), n = 512 81.0 (77.1-84.4), n = 489 6.2 0.71 (0.51-0.98) .034 
  PET2+ 69.2 (54.1-80.1), n = 51 54.7 (40.0-67.2), n = 54 14.5 0.60 (0.32-1.15) .117 
 ≥60 y 70.5 (58.6-79.5), n = 84 66.5 (55.9-75.2), n = 102 4.0 0.79 (0.46-1.33) .366 
  PET2− 75.2 (62.1-84.3), n = 65 70.9 (59.8-79.5), n = 84 4.3 0.70 (0.38-1.30) .258 
  PET2+ 57.1 (17.2-83.7), n = 7 33.3 (7.8-62.3), n = 9 23.8 0.65 (0.16-2.63) .545 
*

HRs (A+AVD/ABVD) and 95% CIs are based a Cox proportional hazard regression model, which is stratified for the ITT population and unstratified for subgroup analyses.

†

P values are calculated using a log-rank test, which is stratified for the ITT population and unstratified for subgroup analyses.

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