Comparison of hematological parameters among SS, SS-Selp−/−, and Selp−/− mice
| Parameter . | Normal range . | SS, mean ± SD . | SS-Selp−/−, mean ± SD . | Selp−/−, mean ± SD . | P . |
|---|---|---|---|---|---|
| WBCs, ×109/L | 1.8-10.7 | 29.4 ± 13 | 46.9 ± 5 | 4.5 ± 1 | .01*; <.01† |
| Neutrophils, ×109/L | 0.1-2.4 | 6.7 ± 4 | 23.3 ± 7 | 0.8 ± 0.7 | .01*; <.01† |
| Lymphocytes, ×109/L | 0.9-9.3 | 21.3 ± 8 | 19.8 ± 4 | 3.3 ± 1 | .70; <.01† |
| Monocytes, ×109/L | 0.0-0.4 | 1.3 ± 1 | 3.2 ± 1 | 0.4 ± 0.1 | .04*; .02† |
| Platelets, ×109/L | 592-2972 | 306.3 ± 81 | 458.8 ± 104 | 888.5 ± 140 | .05; <.01† |
| Hemoglobin, g/dL | 11.0-15.1 | 6.9 ± 1 | 7.3 ± 1 | 11.6 ± 0.4 | .61; <.01† |
| Hematocrit, % | 35.1-45.4 | 26.9 ± 5 | 25.8 ± 5 | 46.7 ± 2 | .72; <.01† |
| Parameter . | Normal range . | SS, mean ± SD . | SS-Selp−/−, mean ± SD . | Selp−/−, mean ± SD . | P . |
|---|---|---|---|---|---|
| WBCs, ×109/L | 1.8-10.7 | 29.4 ± 13 | 46.9 ± 5 | 4.5 ± 1 | .01*; <.01† |
| Neutrophils, ×109/L | 0.1-2.4 | 6.7 ± 4 | 23.3 ± 7 | 0.8 ± 0.7 | .01*; <.01† |
| Lymphocytes, ×109/L | 0.9-9.3 | 21.3 ± 8 | 19.8 ± 4 | 3.3 ± 1 | .70; <.01† |
| Monocytes, ×109/L | 0.0-0.4 | 1.3 ± 1 | 3.2 ± 1 | 0.4 ± 0.1 | .04*; .02† |
| Platelets, ×109/L | 592-2972 | 306.3 ± 81 | 458.8 ± 104 | 888.5 ± 140 | .05; <.01† |
| Hemoglobin, g/dL | 11.0-15.1 | 6.9 ± 1 | 7.3 ± 1 | 11.6 ± 0.4 | .61; <.01† |
| Hematocrit, % | 35.1-45.4 | 26.9 ± 5 | 25.8 ± 5 | 46.7 ± 2 | .72; <.01† |
Data are reported for 4 male and 3 female SS mice, 4 female SS-Selp−/− mice, and 2 male and 2 female Selp−/− mice.
WBCs, white blood cells.
Significant (P < .05) difference between SS mice and SS-Selp−/− mice, Student t test with unequal variances.
Significant (P < .05) difference between SS-Selp−/− mice and Selp−/− mice, Student t test with unequal variances.