Future targets for VST therapy
| Potential VST targets . | Targets/antigen sources . | Clinical studies . | Reference . |
|---|---|---|---|
| HSV | A02-restricted T cells expanded | None | Ma et al82 |
| VZV | VZV vaccine | Used in prophylaxis post-BMT | Ma et al80 |
| HPV | E6, E7 peptide libraries | Prior use against HPV-associated cancers | McCormack et al83 |
| Respiratory viruses | |||
| Influenza A | Nucleocapsid protein, Matrix protein 1 peptide libraries | None | Vasileiou et al87 |
| Respiratory syncytial virus | Nucleoprotein and glycoprotein F0 protein peptide libraries | None | Vasileiou et al87 |
| Human metapneumovirus | Nucleocapsid, fusion protein peptide libraries | None | Tzannou et al32 |
| Human parainfluenza virus | HPIV3 matrix protein | None published/NCT03180216 | McLaughlin et al81 |
| Enteric viruses | |||
| Norovirus | VP1, NS6 peptide libraries | None | Hanajiri et al |
| Mycobacteria spp. | Ag85B, PPE68, ESAT6, CFP10 peptide libraries (Mycobacteria tuberculosis) | None | Patel et al85 |
| Mucormycosis | Rhizopus oryzae extract | None | Castillo et al86 |
| Potential VST targets . | Targets/antigen sources . | Clinical studies . | Reference . |
|---|---|---|---|
| HSV | A02-restricted T cells expanded | None | Ma et al82 |
| VZV | VZV vaccine | Used in prophylaxis post-BMT | Ma et al80 |
| HPV | E6, E7 peptide libraries | Prior use against HPV-associated cancers | McCormack et al83 |
| Respiratory viruses | |||
| Influenza A | Nucleocapsid protein, Matrix protein 1 peptide libraries | None | Vasileiou et al87 |
| Respiratory syncytial virus | Nucleoprotein and glycoprotein F0 protein peptide libraries | None | Vasileiou et al87 |
| Human metapneumovirus | Nucleocapsid, fusion protein peptide libraries | None | Tzannou et al32 |
| Human parainfluenza virus | HPIV3 matrix protein | None published/NCT03180216 | McLaughlin et al81 |
| Enteric viruses | |||
| Norovirus | VP1, NS6 peptide libraries | None | Hanajiri et al |
| Mycobacteria spp. | Ag85B, PPE68, ESAT6, CFP10 peptide libraries (Mycobacteria tuberculosis) | None | Patel et al85 |
| Mucormycosis | Rhizopus oryzae extract | None | Castillo et al86 |
BMT, bone marrow transplantation; HPV, human papillomavirus; VZV, varicella-zoster virus.