Recommended anatomic measures for MRI of brain in SCD
| 3 Tesla MRI method: anatomical (basic) . | Outcome measure . | Rationale . | Duration, min . |
|---|---|---|---|
| 2D T2w FLAIR (2 planes: axial and coronal) or 3D T2w FLAIR (reconstructed to 3 orthogonal planes) | 1. Infarct (count) | Evaluate presence of prior and new overt strokes or silent cerebral and cerebellar infarcts (SCIs); prior SCI is a risk factor for future SCI | 5-7 (cumulative) |
| 2. White matter lesion (count) | |||
| 3. Alternative pathology (Dx) | |||
| 3D T1w MPRAGE | 1. Infarct (count) | Required with FLAIR to characterize infarct (FLAIR hyperintense, T1 hypointense); progressive tissue atrophy may be associated with cognitive decline | 5 |
| 2. Tissue volume (volume; mm3) | |||
| 2D T2w | 1. Infarct (count) | Adds clarity for temporal lobe lesion identification | 3 |
| 2. Lesion (count) |
| 3 Tesla MRI method: anatomical (basic) . | Outcome measure . | Rationale . | Duration, min . |
|---|---|---|---|
| 2D T2w FLAIR (2 planes: axial and coronal) or 3D T2w FLAIR (reconstructed to 3 orthogonal planes) | 1. Infarct (count) | Evaluate presence of prior and new overt strokes or silent cerebral and cerebellar infarcts (SCIs); prior SCI is a risk factor for future SCI | 5-7 (cumulative) |
| 2. White matter lesion (count) | |||
| 3. Alternative pathology (Dx) | |||
| 3D T1w MPRAGE | 1. Infarct (count) | Required with FLAIR to characterize infarct (FLAIR hyperintense, T1 hypointense); progressive tissue atrophy may be associated with cognitive decline | 5 |
| 2. Tissue volume (volume; mm3) | |||
| 2D T2w | 1. Infarct (count) | Adds clarity for temporal lobe lesion identification | 3 |
| 2. Lesion (count) |
An adjudication committee is strongly recommended for imaging outcomes.
2D, 2-dimensional; Dx, diagnosis; MPRAGE, Magnetization Prepared–RApid Gradient Echo.