Expression of different NK receptors in NK and T-cell lymphomas of cytotoxic phenotype
| Case no. . | Age/ sex . | Site . | Diagnosis . | Immunophenotype . | EA . | TCR γ gene . | Lineage . | CD94 (XA185) . | NKG2A (Z270) . | p58.2 (GL183) . | p58.1 (EB6) . | p140 (Q66) . | p70 (Z27) . | p50.3 (FST172) . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 10/M | Nasal | Nasal T/NK | TIA1+/GrB−/CD3−(p)/CD5−/CD56+/βF1−/TCRδ1− | GL | NK | + | + | − | − | − | − | − | |
| 2 | 30/M | Nasal | Nasal T/NK | TIA1−/GrB+/CD3−(p)/CD5−/CD56+/βF1−/TCRδ1− | GL | NK | + | + | − | − | + | − | − | |
| 3 | 57/M | Oropharynx | Nasal T/NK | TIA1+/GrB+/CD3−(f)/CD5−/CD56+/βF1−/TCRδ1− | GL | NK | + | + | − | − | − | − | − | |
| 4 | 64/M | Nasal | Nasal T/NK | TIA1+/GrB+/CD3+(p)/CD5−/CD56+/βF1−/TCRδ1− | GL | NK | + | + | − | − | − | − | − | |
| 5 | 17/F | Spleen | HS γ/δ TCL | TIA1+/GrB−/CD3+(f)/CD56+/βF1−/TCRδ1+ | mono | T (γδ) | + | + | + | + | − | − | − | |
| 6 | 59/M | Spleen | PTCL NOS | TIA1+/GrB+/CD3+(p)/CD56+/βF1+/TCRδ1− | mono | T (αβ) | − | − | − | − | − | − | − | |
| 7 | 50/F | Small intestine | INKL | TIA1+/GrB−/CD3+(p)CD3−(f)/CD5−/CD56+/βF1−/TCRδ1− | Y | GL | NK | + | + | + | + | − | − | − |
| 8 | 51/M | Small intestine | ITCL | TIA1+/GrB+/CD3+(p&f)/CD5−/CD56−/βF1−/TCRδ1− | Y | nd | T | − | − | − | − | − | − | − |
| 9 | 66/F | Small intestine | ITCL | TIA1+/GrB+/CD3+(p&f)/CD5−/CD56−/βF1−/TCRδ1− | N | nd | T | − | − | − | − | − | − | − |
| 10 | 61/F | Small intestine | ITCL | TIA1+/GrB−/CD3+(p&f)/CD5−/CD56+/βF1−/TCRδ1− | N | mono | T | − | − | − | − | − | − | − |
| 11 | 53/F | Small intestine | ITCL | TIA1+/GrB+/CD3+(p&f)/CD5+/CD56+/βF1+/TCRδ1− | Y | mono | T | − | − | − | − | − | − | − |
| 12 | 52/M | Small intestine | ITCL | TIA1+/GrB+/CD3+(p&f)/CD5−/CD56−/βF1+/TCRδ1− | N | nd | T | − | − | − | − | − | − | − |
| 13 | 66/M | Small intestine | ITCL | TIA1+/GrB−/CD3+(p&f)/CD5+/CD56−/βF1−/TCRδ1− | Y | nd | T | − | − | − | − | − | − | − |
| 14 | 60/M | Small intestine | ITCL | TIA1+/GrB+/CD3+(f)/CD5−/CD56−/βF1−/TCRδ1− | nd | nd | T | + | − | − | − | − | − | − |
| 15 | 63/M | Small intestine | ITCL | TIA1+/GrB−/CD3+(p&f)/CD5−/CD56−/βF1+/TCRδ1− | Y | nd | T | − | − | − | − | − | − | − |
| 16 | 70/F | Small intestine | ITCL | TIA1−/GrB+/CD3+(p&f)/CD5−/CD56−/βF1−/TCRδ1− | Y | nd | T | − | − | − | − | − | − | − |
| 17 | 39/M | Small intestine | ITCL | TIA1+/GrB+/CD3+(p&f)/CD5−/CD56−/βF1+/TCRδ1− | Y | nd | T | + | + | − | − | − | − | − |
| 18 | 35/M | Skin | ALCL | TIA1+/CD3+(p) | nd | T | − | − | − | − | − | − | − | |
| 19 | 57/F | Skin | CD30+ LPD | TIA1+/CD3+(p)/CD5− | nd | T | − | − | − | − | − | − | − | |
| 20 | 26/F | Skin | PTCL NOS | TIA1+/CD3−(p)/CD56+ | mono | T | − | − | − | − | − | − | − |
| Case no. . | Age/ sex . | Site . | Diagnosis . | Immunophenotype . | EA . | TCR γ gene . | Lineage . | CD94 (XA185) . | NKG2A (Z270) . | p58.2 (GL183) . | p58.1 (EB6) . | p140 (Q66) . | p70 (Z27) . | p50.3 (FST172) . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 10/M | Nasal | Nasal T/NK | TIA1+/GrB−/CD3−(p)/CD5−/CD56+/βF1−/TCRδ1− | GL | NK | + | + | − | − | − | − | − | |
| 2 | 30/M | Nasal | Nasal T/NK | TIA1−/GrB+/CD3−(p)/CD5−/CD56+/βF1−/TCRδ1− | GL | NK | + | + | − | − | + | − | − | |
| 3 | 57/M | Oropharynx | Nasal T/NK | TIA1+/GrB+/CD3−(f)/CD5−/CD56+/βF1−/TCRδ1− | GL | NK | + | + | − | − | − | − | − | |
| 4 | 64/M | Nasal | Nasal T/NK | TIA1+/GrB+/CD3+(p)/CD5−/CD56+/βF1−/TCRδ1− | GL | NK | + | + | − | − | − | − | − | |
| 5 | 17/F | Spleen | HS γ/δ TCL | TIA1+/GrB−/CD3+(f)/CD56+/βF1−/TCRδ1+ | mono | T (γδ) | + | + | + | + | − | − | − | |
| 6 | 59/M | Spleen | PTCL NOS | TIA1+/GrB+/CD3+(p)/CD56+/βF1+/TCRδ1− | mono | T (αβ) | − | − | − | − | − | − | − | |
| 7 | 50/F | Small intestine | INKL | TIA1+/GrB−/CD3+(p)CD3−(f)/CD5−/CD56+/βF1−/TCRδ1− | Y | GL | NK | + | + | + | + | − | − | − |
| 8 | 51/M | Small intestine | ITCL | TIA1+/GrB+/CD3+(p&f)/CD5−/CD56−/βF1−/TCRδ1− | Y | nd | T | − | − | − | − | − | − | − |
| 9 | 66/F | Small intestine | ITCL | TIA1+/GrB+/CD3+(p&f)/CD5−/CD56−/βF1−/TCRδ1− | N | nd | T | − | − | − | − | − | − | − |
| 10 | 61/F | Small intestine | ITCL | TIA1+/GrB−/CD3+(p&f)/CD5−/CD56+/βF1−/TCRδ1− | N | mono | T | − | − | − | − | − | − | − |
| 11 | 53/F | Small intestine | ITCL | TIA1+/GrB+/CD3+(p&f)/CD5+/CD56+/βF1+/TCRδ1− | Y | mono | T | − | − | − | − | − | − | − |
| 12 | 52/M | Small intestine | ITCL | TIA1+/GrB+/CD3+(p&f)/CD5−/CD56−/βF1+/TCRδ1− | N | nd | T | − | − | − | − | − | − | − |
| 13 | 66/M | Small intestine | ITCL | TIA1+/GrB−/CD3+(p&f)/CD5+/CD56−/βF1−/TCRδ1− | Y | nd | T | − | − | − | − | − | − | − |
| 14 | 60/M | Small intestine | ITCL | TIA1+/GrB+/CD3+(f)/CD5−/CD56−/βF1−/TCRδ1− | nd | nd | T | + | − | − | − | − | − | − |
| 15 | 63/M | Small intestine | ITCL | TIA1+/GrB−/CD3+(p&f)/CD5−/CD56−/βF1+/TCRδ1− | Y | nd | T | − | − | − | − | − | − | − |
| 16 | 70/F | Small intestine | ITCL | TIA1−/GrB+/CD3+(p&f)/CD5−/CD56−/βF1−/TCRδ1− | Y | nd | T | − | − | − | − | − | − | − |
| 17 | 39/M | Small intestine | ITCL | TIA1+/GrB+/CD3+(p&f)/CD5−/CD56−/βF1+/TCRδ1− | Y | nd | T | + | + | − | − | − | − | − |
| 18 | 35/M | Skin | ALCL | TIA1+/CD3+(p) | nd | T | − | − | − | − | − | − | − | |
| 19 | 57/F | Skin | CD30+ LPD | TIA1+/CD3+(p)/CD5− | nd | T | − | − | − | − | − | − | − | |
| 20 | 26/F | Skin | PTCL NOS | TIA1+/CD3−(p)/CD56+ | mono | T | − | − | − | − | − | − | − |
EA indicates enteropathy association (Y = yes, N = no); HS γδ TCL, hepatosplenic γδ T-cell lymphoma; PTCL NOS, peripheral T-cell lymphoma not otherwise specified; ITCL, intestinal T-cell lymphoma; INKL, intestinal NK cell lymphoma; ALCL, anaplastic large-cell lymphoma; CD30+ LPD, CD30+ lymphoproliferative disorder; p, paraffin sections; f, frozen sections; nd, not done; GL, germline; mono, clonal rearrangement.