Clinical outcomes of patients receiving neutrophil transfusion therapy
| Infection . | N . | Clearance of infection . | Line removal . | Engraft. . | Alive day 304-150 . |
|---|---|---|---|---|---|
| Invasive aspergillosis | 3 | 0/3 | NA | 1/3 | 0/3 |
| Fusariosis | 2 | 0/2 | 0/2 | 1/2 | 0/2 |
| Disseminated candidiasis | 6 | 3/6 | 5/6 | 2/6 | 1/6 |
| Monomicrobial bacteremia | 2 | 2/24-151 | 0/2 | 2/2 | 1/2 |
| Mixed infections | 5 | ||||
| Aspergillosis/bacteremia (VRE) | 0/1 | 0/1 | NA | 0 | |
| Aspergillosis/bacterial pneumonia | 0/1 | NA | 0/1 | 0 | |
| Fungal pneumonia/CMV pneumonia | 0/1 | NA | 0/1 | 0 | |
| Candidemia (C. krusei )/bacteremia (S. maltophilia) | 1/1 | 0/1 | 0/1 | 0 | |
| Mixed bacteremia (S. maltophilia/VRE) | 1/1 | 0/1 | 1/1 | 1 | |
| Neutropenic enterocolitis (typhlitis) | 1 | 1/1 | NA | 1/1 | 1 |
| Any aspergillosis‡,4-153 | 6 | 0/6 | 0/14-155 | 1/6 | 0/6 |
| Any invasive mold infection‡,4-153 | 8 | 0/8 | 0/34-155 | 2/8 | 0/8 |
| Any candidiasis‡ | 7 | 4/7 | 5/7 | 2/7 | 1/7 |
| Bacteremia without concomitant fungal infection4-154 | 4 | 4/4 | 0/34-155 | 4/4 | 3/4 |
| Overall | 19 | 8/19 | 5/13 | 8/19 | 4/19 |
| Infection . | N . | Clearance of infection . | Line removal . | Engraft. . | Alive day 304-150 . |
|---|---|---|---|---|---|
| Invasive aspergillosis | 3 | 0/3 | NA | 1/3 | 0/3 |
| Fusariosis | 2 | 0/2 | 0/2 | 1/2 | 0/2 |
| Disseminated candidiasis | 6 | 3/6 | 5/6 | 2/6 | 1/6 |
| Monomicrobial bacteremia | 2 | 2/24-151 | 0/2 | 2/2 | 1/2 |
| Mixed infections | 5 | ||||
| Aspergillosis/bacteremia (VRE) | 0/1 | 0/1 | NA | 0 | |
| Aspergillosis/bacterial pneumonia | 0/1 | NA | 0/1 | 0 | |
| Fungal pneumonia/CMV pneumonia | 0/1 | NA | 0/1 | 0 | |
| Candidemia (C. krusei )/bacteremia (S. maltophilia) | 1/1 | 0/1 | 0/1 | 0 | |
| Mixed bacteremia (S. maltophilia/VRE) | 1/1 | 0/1 | 1/1 | 1 | |
| Neutropenic enterocolitis (typhlitis) | 1 | 1/1 | NA | 1/1 | 1 |
| Any aspergillosis‡,4-153 | 6 | 0/6 | 0/14-155 | 1/6 | 0/6 |
| Any invasive mold infection‡,4-153 | 8 | 0/8 | 0/34-155 | 2/8 | 0/8 |
| Any candidiasis‡ | 7 | 4/7 | 5/7 | 2/7 | 1/7 |
| Bacteremia without concomitant fungal infection4-154 | 4 | 4/4 | 0/34-155 | 4/4 | 3/4 |
| Overall | 19 | 8/19 | 5/13 | 8/19 | 4/19 |
NA indicates not applicable; VRE, vancomycin-resistant enterococci; CMV, cytomegalovirus.
After onset of infection.
One patient cleared infection before first transfusion.
With and without copathogens.
One patient with septate hyphae on lung biopsy included (patient #17).
Denominator does not include those cases for which line removal would not be applicable (eg, invasive aspergillosis, typhlitis).
One patient with neutropenic enterocolitis included (#16).