IgH Rearrangements in the B-Precursor Leukemias From Eμ-ret Mice
| Mouse . | Age (wks) . | V Family . | 3′ V . | pNp . | D or Unknown . | pNp . | 5′ J . | J # . | D Family . | P/NP . |
|---|---|---|---|---|---|---|---|---|---|---|
| 2/19 | 20 | J558 | TGTGCAAGA | AG | ACT*AC | *TACTTT | 2 | SP or FL | NP | |
| 6/26 | 18 | Q52 | TGTGCC | CCC | CTATGGTAACT*AC | *TACTTT | 2 | SP | NP | |
| 7183 | TGTGCAAGAC | ? | GCGGAGG | ? | CCTGGT | 3 | ? | NP | ||
| 5/9 | 38 | Q52 | TGTGCCAGAAA | ATA*GGT | *TTGCTT | 3 | SP | P | ||
| J558 | TGTACAAGA | GGGGCT | TCTATGA*T | *TTGACT | 2 | SP | NP | |||
| 6/14 | 24 | Q52 | TGTGCCAGA | CATAA | ATTACTACGGTAGTAG*CT | *GGGGCC | 3 | FL | NP | |
| J558 | TGTGCACA* | A*CTATAGGTACGAC | GCTATG | 4 | SP | NP | ||||
| 7/1 | 10 | 7183 | TGTGCAAGACA | tAG | TATGATTACG | CCTGGT | 3 | SP | NP | |
| 2/28 | 22 | 7183 | TGTGCAAG | GG | A*ACTAC | *TGGGGC | 2 | SP | NP | |
| J558 | TGTGCAAGA | GGGGGGG | ATGGTAACTAC | TTC | ACTGGG | 3 | SP | NP | ||
| 2/17 | 22 | 7183 | GGCCACGTA | ? | CAA | ? | AAGGCA | 2 | ? | NP |
| 558 | TGTGCAAGA | GG | ATGGTAACT | TC | CCTGGT | 3 | SP | NP | ||
| 2/22 | 16 | 7183 | TGTGCAAGAG | GGG | ACGGTAGTAG | TGGTAC | 1 | FL | NP | |
| J558 | TGTGCAAGA | GGTA | ACTACG*GCT | *TACTGG | 3 | FL | NP | |||
| 7/8 | 14 | 3660 | TGCAAG | AGGGGATTa | TCTACTATGATTACGAC | gtGG | GCTTAC | 3 | SP | NP |
| Mouse . | Age (wks) . | V Family . | 3′ V . | pNp . | D or Unknown . | pNp . | 5′ J . | J # . | D Family . | P/NP . |
|---|---|---|---|---|---|---|---|---|---|---|
| 2/19 | 20 | J558 | TGTGCAAGA | AG | ACT*AC | *TACTTT | 2 | SP or FL | NP | |
| 6/26 | 18 | Q52 | TGTGCC | CCC | CTATGGTAACT*AC | *TACTTT | 2 | SP | NP | |
| 7183 | TGTGCAAGAC | ? | GCGGAGG | ? | CCTGGT | 3 | ? | NP | ||
| 5/9 | 38 | Q52 | TGTGCCAGAAA | ATA*GGT | *TTGCTT | 3 | SP | P | ||
| J558 | TGTACAAGA | GGGGCT | TCTATGA*T | *TTGACT | 2 | SP | NP | |||
| 6/14 | 24 | Q52 | TGTGCCAGA | CATAA | ATTACTACGGTAGTAG*CT | *GGGGCC | 3 | FL | NP | |
| J558 | TGTGCACA* | A*CTATAGGTACGAC | GCTATG | 4 | SP | NP | ||||
| 7/1 | 10 | 7183 | TGTGCAAGACA | tAG | TATGATTACG | CCTGGT | 3 | SP | NP | |
| 2/28 | 22 | 7183 | TGTGCAAG | GG | A*ACTAC | *TGGGGC | 2 | SP | NP | |
| J558 | TGTGCAAGA | GGGGGGG | ATGGTAACTAC | TTC | ACTGGG | 3 | SP | NP | ||
| 2/17 | 22 | 7183 | GGCCACGTA | ? | CAA | ? | AAGGCA | 2 | ? | NP |
| 558 | TGTGCAAGA | GG | ATGGTAACT | TC | CCTGGT | 3 | SP | NP | ||
| 2/22 | 16 | 7183 | TGTGCAAGAG | GGG | ACGGTAGTAG | TGGTAC | 1 | FL | NP | |
| J558 | TGTGCAAGA | GGTA | ACTACG*GCT | *TACTGG | 3 | FL | NP | |||
| 7/8 | 14 | 3660 | TGCAAG | AGGGGATTa | TCTACTATGATTACGAC | gtGG | GCTTAC | 3 | SP | NP |
N …* enclose nucleotides that could be assigned to either gene segment and thus represent regions of overlapping homology. P/NP signifies whether the rearrangements were productive (P) or nonproductive (NP). P (p) nucleotides as defined by Lafaille et al18 are shown in lowercase.