Assessment of GVHD Tissue Damage in IUT and Postnatal BMT Recipients
| Group . | BM Dose (×106) . | Liver . | Lung . | Colon . | Spleen . |
|---|---|---|---|---|---|
| IUT congenic | 4.0 | 0.0 (0.0) | 0.3 (0.3) | 0.3 (0.3) | 0.0 (0.0) |
| IUT TCD | 4.0 | 0.0 (0.0) | 0.6 (0.2) | 0.8 (0.2) | 0.5 (0.2)* |
| IUT NTCD | 4.0 | 0.0 (0.0) | 1.2 (0.4) | 0.1 (0.1) | 0.4 (0.2) |
| SCID TCD | 25.0 | 1.4 (0.7)† | 2.3 (0.2)* | 1.1 (0.4) | 1.0 (0.0)* |
| SCID NTCD | 25.0 | 2.4 (0.3)* | 1.9 (0.5)* | 1.0 (0.6) | 1.8 (0.3)* |
| TBI TCD | 4.0 | 0.1 (0.1) | 0.3 (0.3) | 0.5 (0.2) | 0.0 (0.0) |
| Group . | BM Dose (×106) . | Liver . | Lung . | Colon . | Spleen . |
|---|---|---|---|---|---|
| IUT congenic | 4.0 | 0.0 (0.0) | 0.3 (0.3) | 0.3 (0.3) | 0.0 (0.0) |
| IUT TCD | 4.0 | 0.0 (0.0) | 0.6 (0.2) | 0.8 (0.2) | 0.5 (0.2)* |
| IUT NTCD | 4.0 | 0.0 (0.0) | 1.2 (0.4) | 0.1 (0.1) | 0.4 (0.2) |
| SCID TCD | 25.0 | 1.4 (0.7)† | 2.3 (0.2)* | 1.1 (0.4) | 1.0 (0.0)* |
| SCID NTCD | 25.0 | 2.4 (0.3)* | 1.9 (0.5)* | 1.0 (0.6) | 1.8 (0.3)* |
| TBI TCD | 4.0 | 0.1 (0.1) | 0.3 (0.3) | 0.5 (0.2) | 0.0 (0.0) |
Coded tissue samples from 4 high-level chimeras per group were analyzed using a semiquantitative GVH scoring system. Data are the mean values of the individual scores and in parentheses is shown one standard error of the mean.
P ≤ .05 versus IUT congenic recipients.
.05 < P < .1 versus IUT congenic recipients.