Clinical Outcome After Hematopoietic Stem Cell Transplantation for MS
| Patient . | Time Since Transplant (mo) . | Stable or Improved Disease (mo) . | No. of Relapses . | EDSS Pretransplant and Most Recent Posttransplant . | NRS Pretransplant and Most Recent Posttransplant . | MRI . | Neurological Changes . |
|---|---|---|---|---|---|---|---|
| MS #1 secondary progressive | 17 | 17 | 0 | 8.5/8.5 | 15/19 | No new lesions | Improved cognition, decreased incontinence |
| MS #2 secondary progressive | 16 | 16 | 0 | 8.0/8.0 | 30/29 | No new lesions | Decreased incontinence, decreased tremor |
| MS #3 primary progressive | 15 | 15 | 0 | 8.0/8.0 | 34/37 | No new lesions | Improved stamina and strength, now able to swim |
| MS #4 secondary progressive | 6 | 6 | 0 | 6.5/6.0 | 49/63 | No new lesions | Less dysarthria, correction of gaze deviation |
| MS #5 primary progressive | 5 | 5 | 0 | 7.0/6.5 | 29/58 | No new lesions | Improved strength |
| MS #6 secondary progressive | 5 | 5 | 0 | 6.0/6.0 | 51/61 | No new lesions | Improved strength and cerebellar function |
| Patient . | Time Since Transplant (mo) . | Stable or Improved Disease (mo) . | No. of Relapses . | EDSS Pretransplant and Most Recent Posttransplant . | NRS Pretransplant and Most Recent Posttransplant . | MRI . | Neurological Changes . |
|---|---|---|---|---|---|---|---|
| MS #1 secondary progressive | 17 | 17 | 0 | 8.5/8.5 | 15/19 | No new lesions | Improved cognition, decreased incontinence |
| MS #2 secondary progressive | 16 | 16 | 0 | 8.0/8.0 | 30/29 | No new lesions | Decreased incontinence, decreased tremor |
| MS #3 primary progressive | 15 | 15 | 0 | 8.0/8.0 | 34/37 | No new lesions | Improved stamina and strength, now able to swim |
| MS #4 secondary progressive | 6 | 6 | 0 | 6.5/6.0 | 49/63 | No new lesions | Less dysarthria, correction of gaze deviation |
| MS #5 primary progressive | 5 | 5 | 0 | 7.0/6.5 | 29/58 | No new lesions | Improved strength |
| MS #6 secondary progressive | 5 | 5 | 0 | 6.0/6.0 | 51/61 | No new lesions | Improved strength and cerebellar function |
The EDSS is divided into 20 half points from 0 (normal) to 10 (death). Increasing points indicate worse neurologic deficits. In the higher range (5.0 to 8.0), the EDSS is weighted by ambulation. For example, ambulation less than 200 meters without assist is 5.0; wheelchair bound is 8.0. In the NRS, normal neurologic function is 100 points, whereas lower numbers indicate progressive neurologic disability.
Abbreviations: EDSS, Kurtzke extended status disability scale21; MRI, magnetic resonance spectroscopy; NRS, Scripps Neurologic Rating Scale.25