Hematopoietic Stem Cell Collection in Patients With Autoimmune Diseases
| Patient . | Method of PBSC Collection . | No. of Apheresis . | CD34+ Cells/kg Infused ×106 . | CD3+ Cells/kg Infused ×106 (log depletion) . | CD19+ Cells/kg Infused ×106 (log depletion) . |
|---|---|---|---|---|---|
| MS #1 | G-CSF | 2 plus 1 bone marrow harvest | 2.12 | 0.50 (2.5) | 0.12 (2.51) |
| MS #2 | G-CSF | 2 plus 1 bone marrow harvest | 3.91 | 1.4 (1.93) | 1.0 (1.9) |
| MS #3 | G-CSF | 2 plus 1 bone marrow harvest | 2.42 | 1.06 (2.2) | 0.5 (1.9) |
| MS #4 | G-CSF | 1 | 2.57 | 0.23 (2.6) | 1.28 (1.6) |
| MS #5 | G-CSF | 1 | 2.02 | 1.04 (2.5) | 0.23 (2.3) |
| MS #6 | G-CSF | 1 | 2.76 | 0.26 (2.86) | 0.72 (1.92) |
| SLE #1 | Cy + G-CSF | 3 | 2.46 | 1.5 (1.4) | 0.0004 (3.74) |
| SLE #2 | Cy + G-CSF | 5 | 2.0 | 1.0 (2.0) | 0.06 (2.51) |
| RA #1 | Cy + G-CSF | 2 | 2.16 | 0.86 (2.7) | 0.12 (2.18) |
| RA #2 | Cy + G-CSF | 1 | 6.32 | 0.60 (2.5) | 0.10 (2.43) |
| Patient . | Method of PBSC Collection . | No. of Apheresis . | CD34+ Cells/kg Infused ×106 . | CD3+ Cells/kg Infused ×106 (log depletion) . | CD19+ Cells/kg Infused ×106 (log depletion) . |
|---|---|---|---|---|---|
| MS #1 | G-CSF | 2 plus 1 bone marrow harvest | 2.12 | 0.50 (2.5) | 0.12 (2.51) |
| MS #2 | G-CSF | 2 plus 1 bone marrow harvest | 3.91 | 1.4 (1.93) | 1.0 (1.9) |
| MS #3 | G-CSF | 2 plus 1 bone marrow harvest | 2.42 | 1.06 (2.2) | 0.5 (1.9) |
| MS #4 | G-CSF | 1 | 2.57 | 0.23 (2.6) | 1.28 (1.6) |
| MS #5 | G-CSF | 1 | 2.02 | 1.04 (2.5) | 0.23 (2.3) |
| MS #6 | G-CSF | 1 | 2.76 | 0.26 (2.86) | 0.72 (1.92) |
| SLE #1 | Cy + G-CSF | 3 | 2.46 | 1.5 (1.4) | 0.0004 (3.74) |
| SLE #2 | Cy + G-CSF | 5 | 2.0 | 1.0 (2.0) | 0.06 (2.51) |
| RA #1 | Cy + G-CSF | 2 | 2.16 | 0.86 (2.7) | 0.12 (2.18) |
| RA #2 | Cy + G-CSF | 1 | 6.32 | 0.60 (2.5) | 0.10 (2.43) |
Abbreviation: Cy, cyclophosphamide (2.0 g/m2).