Univariate and Multivariate Analyses of Risk Factors for Hepatic VOD
| Factor . | No. With VOD/ No. Evaluable (%) . | Univariate Analysis P Value . | Multivariate Analysis P Value . | RR (95% CI) . |
|---|---|---|---|---|
| Patient-related factors | ||||
| Age >20 yr | ||||
| No | 21/306 (6.9) | NS | ||
| Yes | 66/1,346 (4.9) | |||
| Previous abdominal radiation | ||||
| No | 80/1,599 (5.0) | .009 | .03 | 2.9 |
| Yes | 7/53 (13.2) | (1.2-6.9) | ||
| Second BMT | ||||
| No | 84/1,617 (5.2) | NS | ||
| Yes | 3/35 (8.6) | |||
| Previous liver disease | ||||
| No | 76/1,566 (4.9) | .0013 | ||
| Yes | 11/86 (12.8) | |||
| Increased serum AST level | ||||
| No | 70/1,524 (4.6) | <.0001 | .001 | 2.4 |
| Yes | 17/128 (13.3) | (1.3-4.3) | ||
| Karnofsky score <90% | ||||
| No | 73/1,544 (4.7) | .0002 | .006 | 2.7 |
| Yes | 14/198 (13.0) | (1.4-5) | ||
| Fungal infection before BMT | ||||
| No | 86/1,637 (5.3) | NS | ||
| Yes | 1/15 (6.7) | |||
| Transplant-related factors | ||||
| Pretransplant acyclovir | ||||
| No | 71/1,381 (5.1) | NS | ||
| Yes | 16/271 (5.9) | |||
| Vancomycin during CT | ||||
| No | 77/1,514 (5.1) | NS | ||
| Yes | 10/138 (7.2) | |||
| Dose of CT | ||||
| Low | 13/539 (2.4) | .0003 | .003 | 2.3 |
| High | 74/1,113 (6.6) | (1.2-4.2) | ||
| Type of transplant | ||||
| Allogeneic | 56/631 (8.9) | <.0001 | <.001 | 2.8 |
| Autologous | 31/1,010 (3.1) | (1.8-4.4) |
| Factor . | No. With VOD/ No. Evaluable (%) . | Univariate Analysis P Value . | Multivariate Analysis P Value . | RR (95% CI) . |
|---|---|---|---|---|
| Patient-related factors | ||||
| Age >20 yr | ||||
| No | 21/306 (6.9) | NS | ||
| Yes | 66/1,346 (4.9) | |||
| Previous abdominal radiation | ||||
| No | 80/1,599 (5.0) | .009 | .03 | 2.9 |
| Yes | 7/53 (13.2) | (1.2-6.9) | ||
| Second BMT | ||||
| No | 84/1,617 (5.2) | NS | ||
| Yes | 3/35 (8.6) | |||
| Previous liver disease | ||||
| No | 76/1,566 (4.9) | .0013 | ||
| Yes | 11/86 (12.8) | |||
| Increased serum AST level | ||||
| No | 70/1,524 (4.6) | <.0001 | .001 | 2.4 |
| Yes | 17/128 (13.3) | (1.3-4.3) | ||
| Karnofsky score <90% | ||||
| No | 73/1,544 (4.7) | .0002 | .006 | 2.7 |
| Yes | 14/198 (13.0) | (1.4-5) | ||
| Fungal infection before BMT | ||||
| No | 86/1,637 (5.3) | NS | ||
| Yes | 1/15 (6.7) | |||
| Transplant-related factors | ||||
| Pretransplant acyclovir | ||||
| No | 71/1,381 (5.1) | NS | ||
| Yes | 16/271 (5.9) | |||
| Vancomycin during CT | ||||
| No | 77/1,514 (5.1) | NS | ||
| Yes | 10/138 (7.2) | |||
| Dose of CT | ||||
| Low | 13/539 (2.4) | .0003 | .003 | 2.3 |
| High | 74/1,113 (6.6) | (1.2-4.2) | ||
| Type of transplant | ||||
| Allogeneic | 56/631 (8.9) | <.0001 | <.001 | 2.8 |
| Autologous | 31/1,010 (3.1) | (1.8-4.4) |
Abbreviations: CT, cytoreductive therapy; AST, aspartate aminotransferase; NS, not significant.