Analysis of VH Gene Mutations in PCBCLs
| Patient No. . | FR/CDR . | Observed . | Expected R/S4-150 . | P Value . | ||
|---|---|---|---|---|---|---|
| R . | S . | R/S . | ||||
| 1 | FR | 6 | 2 | 3 | 3.3 | .066 |
| CDR | 6 | 1 | 6 | 3.5 | ||
| 2 | FR | 10 | 8 | 1.3 | 2.8 | <.01 |
| CDR | 7 | 4 | 1.8 | 4.9 | ||
| 3 | FR | 18 | 19 | 0.95 | 2.9 | <.001 |
| CDR | 8 | 7 | 1.1 | 3.5 | ||
| 4 | FR | 2 | 8 | 0.25 | 2.8 | <.001 |
| CDR | 4 | 1 | 4 | 4.9 | ||
| 5 | FR | 1 | 8 | 0.13 | 2.9 | <.0001 |
| CDR | 5 | 3 | 1.7 | 3.9 | ||
| 6 | FR | 12 | 15 | 0.8 | 2.6 | <.01 |
| CDR | 2 | 6 | 0.33 | 4.5 | ||
| 7 | FR | 20 | 9 | 2.2 | 3.0 | .12 |
| CDR | 7 | 1 | 7 | 4.3 | ||
| Patient No. . | FR/CDR . | Observed . | Expected R/S4-150 . | P Value . | ||
|---|---|---|---|---|---|---|
| R . | S . | R/S . | ||||
| 1 | FR | 6 | 2 | 3 | 3.3 | .066 |
| CDR | 6 | 1 | 6 | 3.5 | ||
| 2 | FR | 10 | 8 | 1.3 | 2.8 | <.01 |
| CDR | 7 | 4 | 1.8 | 4.9 | ||
| 3 | FR | 18 | 19 | 0.95 | 2.9 | <.001 |
| CDR | 8 | 7 | 1.1 | 3.5 | ||
| 4 | FR | 2 | 8 | 0.25 | 2.8 | <.001 |
| CDR | 4 | 1 | 4 | 4.9 | ||
| 5 | FR | 1 | 8 | 0.13 | 2.9 | <.0001 |
| CDR | 5 | 3 | 1.7 | 3.9 | ||
| 6 | FR | 12 | 15 | 0.8 | 2.6 | <.01 |
| CDR | 2 | 6 | 0.33 | 4.5 | ||
| 7 | FR | 20 | 9 | 2.2 | 3.0 | .12 |
| CDR | 7 | 1 | 7 | 4.3 | ||
P values are the probability that the number of R mutations observed in the FRs was obtained by chance. Pvalues in boldface type indicate significance (P < .01).
See Chang and Casali.10