Effects of Antagonists on AP5 and PMI-1 Expression and OP-G2 Binding
| αIIbβ3 Antagonist . | AP5 Expression ED50 (nmol/L) (n = 6) . | Anti-LIBS1 Expression ED50 (nmol/L) (n = 3) . | Anti-LIBS2 Expression ED50(nmol/L) (n = 3) . | PMI-1 Expression ED50(nmol/L) (n = 3) . | OP-G2 Binding IC50(nmol/L) (n = 3) . | PMI-1/FBG Ratio . | OP-G2/FBG Ratio . | Group . |
|---|---|---|---|---|---|---|---|---|
| FR184764 | 104.5 ± 61.5 | 48.0 ± 11.8 | 270.0 ± 104.4 | 226.7 ± 36.8 | 583.3 ± 102.7 | 25.2 | 64.8 | |
| SC54701 | 173.0 ± 74.5 | 95.0 ± 35.0 | 443.3 ± 136.5 | 246.7 ± 103.7 | 1,233.3 ± 262.5 | 21.5 | 107.2 | I |
| FR169824 | 258.3 ± 75.7 | 150.0 ± 43.6 | 560.0 ± 87.1 | 290.0 ± 96.3 | 1,866.7 ± 368.2 | 14.7 | 94.8 | |
| FK633 | 520.0 ± 195.2 | 260.0 ± 121.2 | 1,230.0 ± 311.0 | 2,266.7 ± 1,228.4 | 5,600.0 ± 496.7 | 57.7 | 142.5 | |
| Ro44-9883 | (−) | (−) | (−) | 3.3 ± 1.4 | 5.8 ± 0.8 | 0.75 | 1.3 | II |
| MK383 | (−) | (−) | (−) | 14.7 ± 7.5 | 46.7 ± 8.1 | 2.4 | 7.7 |
| αIIbβ3 Antagonist . | AP5 Expression ED50 (nmol/L) (n = 6) . | Anti-LIBS1 Expression ED50 (nmol/L) (n = 3) . | Anti-LIBS2 Expression ED50(nmol/L) (n = 3) . | PMI-1 Expression ED50(nmol/L) (n = 3) . | OP-G2 Binding IC50(nmol/L) (n = 3) . | PMI-1/FBG Ratio . | OP-G2/FBG Ratio . | Group . |
|---|---|---|---|---|---|---|---|---|
| FR184764 | 104.5 ± 61.5 | 48.0 ± 11.8 | 270.0 ± 104.4 | 226.7 ± 36.8 | 583.3 ± 102.7 | 25.2 | 64.8 | |
| SC54701 | 173.0 ± 74.5 | 95.0 ± 35.0 | 443.3 ± 136.5 | 246.7 ± 103.7 | 1,233.3 ± 262.5 | 21.5 | 107.2 | I |
| FR169824 | 258.3 ± 75.7 | 150.0 ± 43.6 | 560.0 ± 87.1 | 290.0 ± 96.3 | 1,866.7 ± 368.2 | 14.7 | 94.8 | |
| FK633 | 520.0 ± 195.2 | 260.0 ± 121.2 | 1,230.0 ± 311.0 | 2,266.7 ± 1,228.4 | 5,600.0 ± 496.7 | 57.7 | 142.5 | |
| Ro44-9883 | (−) | (−) | (−) | 3.3 ± 1.4 | 5.8 ± 0.8 | 0.75 | 1.3 | II |
| MK383 | (−) | (−) | (−) | 14.7 ± 7.5 | 46.7 ± 8.1 | 2.4 | 7.7 |
Values are given as the mean ± SD with indicated (n).
Abbreviations: FBG, fibrinogen; PMI-1/FBG ratio, ED50 for PMI-1 epitope expression/IC50 for FBG binding; OP-G2/FBG ratio, IC50 for OP-G2 binding/IC50 for FBG binding.