Patient Characteristics and Treatment Response
| Patient No./UPN . | Age/ Sex . | Diagnosis at BMT . | Diagnosis at Relapse . | Tx Before DLI . | Cells/kg Infused at DLI . | Onset GVHD (wk) . | Start of Tx for GVHD (wk) . | Response . | |
|---|---|---|---|---|---|---|---|---|---|
| CD3 ×108 . | CD34 ×106 . | ||||||||
| 1/113 | 43/F | CML CP | CML CP | — | 3.7 | 2.3 | 13 | 14 | mol CR |
| 2/396 | 45/M | CML CP | CML CP | Hydroxyurea | 3.8 | — | 21 | 26 | mol CR |
| 3/338 | 23/M | CML CP | CML mol relapse | — | 1.8 | 2.4 | 12 | 15 | mol CR |
| 4/196 | 54/M | CML CP | CML CP | IFN | 1.6 | 18.2 | 9 | 14 | hem CR |
| 5/311 | 22/M | CML CP | CML CP | — | 1.7 | 1.1 | 7 | 15 | mol CR |
| 6/384 | 20/F | CML CP | CML CP | — | 1.2 | 2.4 | 7 | 10 | mol CR |
| 7/450 | 36/M | CML CP | CML mBC | Ida/AraC | 1.3 | 5.8 | 2 | — | hem CR |
| 8/468 | 39/M | CML CP | CML mBC | IFN, Ida/AraC | 0.8 | 1.6 | 8 | 22 | mol CR |
| Patient No./UPN . | Age/ Sex . | Diagnosis at BMT . | Diagnosis at Relapse . | Tx Before DLI . | Cells/kg Infused at DLI . | Onset GVHD (wk) . | Start of Tx for GVHD (wk) . | Response . | |
|---|---|---|---|---|---|---|---|---|---|
| CD3 ×108 . | CD34 ×106 . | ||||||||
| 1/113 | 43/F | CML CP | CML CP | — | 3.7 | 2.3 | 13 | 14 | mol CR |
| 2/396 | 45/M | CML CP | CML CP | Hydroxyurea | 3.8 | — | 21 | 26 | mol CR |
| 3/338 | 23/M | CML CP | CML mol relapse | — | 1.8 | 2.4 | 12 | 15 | mol CR |
| 4/196 | 54/M | CML CP | CML CP | IFN | 1.6 | 18.2 | 9 | 14 | hem CR |
| 5/311 | 22/M | CML CP | CML CP | — | 1.7 | 1.1 | 7 | 15 | mol CR |
| 6/384 | 20/F | CML CP | CML CP | — | 1.2 | 2.4 | 7 | 10 | mol CR |
| 7/450 | 36/M | CML CP | CML mBC | Ida/AraC | 1.3 | 5.8 | 2 | — | hem CR |
| 8/468 | 39/M | CML CP | CML mBC | IFN, Ida/AraC | 0.8 | 1.6 | 8 | 22 | mol CR |
Clinical data of patient no. 1 and patients no. 3 through 8 were reported previously.3
Abbreviations: CP, chronic phase; mBC, myeloid blast crisis; Tx, treatment; IFN, interferon α; Ida/AraC, induction course by idarubicin and araC; GVHD, graft-versus-host disease; DLI, donor lymphocyte (+/− peripheral stem cell) infusion; mol, molecular; hem, hematologic; CR, complete remission; UPN, unique patient number.