Evidence that heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder.
| . | . | Thrombosis Rate in: . | . | ||
|---|---|---|---|---|---|
| Patient Population . | Thrombosis . | HIT Patients . | Controls . | Odds Ratio (95% CI) . | P . |
| Postorthopedic surgery†24,25 | Proximal DVT | 8/18 (44.4%) | 26/647 (4.0%) | 19.1 (5.9–58.3) | < .001 |
| Bilateral proximal DVT | 2/18 (11.1%) | 4/647 (0.6%) | 20.1 (1.7–150) | .01 | |
| Pulmonary embolism | 2/18 (11.1%) | 2/647 (0.3%) | 40.3 (2.7–572) | .004 | |
| Any thrombosis | 13/18 (72.2%) | 112/647 (17.3%) | 12.4 (4.0–45.2) | < .001 | |
| Patients with central line‡26 | Upper-limb DVT | 14/145 (9.7%) | 3/484 (0.6%) | 17.1 (4.9–60.5) | < .001 |
| Medical†27 | Any thrombosis | 3/5 (60%) | 21/593 (3.5%) | 40.8 (5.2–163) | < .001 |
| . | . | Thrombosis Rate in: . | . | ||
|---|---|---|---|---|---|
| Patient Population . | Thrombosis . | HIT Patients . | Controls . | Odds Ratio (95% CI) . | P . |
| Postorthopedic surgery†24,25 | Proximal DVT | 8/18 (44.4%) | 26/647 (4.0%) | 19.1 (5.9–58.3) | < .001 |
| Bilateral proximal DVT | 2/18 (11.1%) | 4/647 (0.6%) | 20.1 (1.7–150) | .01 | |
| Pulmonary embolism | 2/18 (11.1%) | 2/647 (0.3%) | 40.3 (2.7–572) | .004 | |
| Any thrombosis | 13/18 (72.2%) | 112/647 (17.3%) | 12.4 (4.0–45.2) | < .001 | |
| Patients with central line‡26 | Upper-limb DVT | 14/145 (9.7%) | 3/484 (0.6%) | 17.1 (4.9–60.5) | < .001 |
| Medical†27 | Any thrombosis | 3/5 (60%) | 21/593 (3.5%) | 40.8 (5.2–163) | < .001 |