Human Fc receptors: Common names, functions and distribution.
| Fc Receptor . | Ig Specificity . | Function . | Signaling . | Distribution . |
|---|---|---|---|---|
| CD16a, FcγRIII | IgG | Activation | FcεRIγ, ζ | NK, macrophage, T subset |
| CD16b, FcγRIII | IgG | ? | Neutrophils | |
| CD32a, FcγRIIA | IgG | Activation | Intrinsic ITAM | Myeloid, B |
| CD32b1, FcγRIIB | IgG | Inhibitory | ITIM | Myeloid, B |
| CD64, FcγRI | IgG | Activation | FcεRIγ | Myeloid |
| CD89, FcαRI | IgA | Activation | FcεRIγ | Myeloid |
| Polymeric Ig | IgM, IgA | Transcytosis | Epithelial cells | |
| Fcα/μR | IgM, IgA | Endocytosis | Macrophage, B | |
| FcεRI | IgE (high affinity) | Activation | FcεRIγ, FcεRIβ | Mast cells, basophils |
| FcRn | IgG | Transcytosis | Epithelial cells, myeloid | |
| CD23 | IgE (low affinity | Endocytosis | B |
| Fc Receptor . | Ig Specificity . | Function . | Signaling . | Distribution . |
|---|---|---|---|---|
| CD16a, FcγRIII | IgG | Activation | FcεRIγ, ζ | NK, macrophage, T subset |
| CD16b, FcγRIII | IgG | ? | Neutrophils | |
| CD32a, FcγRIIA | IgG | Activation | Intrinsic ITAM | Myeloid, B |
| CD32b1, FcγRIIB | IgG | Inhibitory | ITIM | Myeloid, B |
| CD64, FcγRI | IgG | Activation | FcεRIγ | Myeloid |
| CD89, FcαRI | IgA | Activation | FcεRIγ | Myeloid |
| Polymeric Ig | IgM, IgA | Transcytosis | Epithelial cells | |
| Fcα/μR | IgM, IgA | Endocytosis | Macrophage, B | |
| FcεRI | IgE (high affinity) | Activation | FcεRIγ, FcεRIβ | Mast cells, basophils |
| FcRn | IgG | Transcytosis | Epithelial cells, myeloid | |
| CD23 | IgE (low affinity | Endocytosis | B |