Changes in F cells and fetal hemoglobin (HbF) following decitabine treatment.
| Patients . | Pre-tx F Cell % . | Max F Cell % . | P Value . | Pre-tx HbF % . | Max HbF % . | P Value . |
|---|---|---|---|---|---|---|
| Abbreviations: Tx, treatment; HU, hydroxyurea. | ||||||
| HU nonresponders (n = 3) | 16.2 ± 10.8 | 55.1 ± 11.1 | 0.002 | 2.4 ± 1.6 | 14.5 ± 2.2 | 0.0006 |
| HU responders (n = 5) | 51.3 ± 6.3 | 81.2 ± 4.4 | 0.0001 | 9.0 ± 2.5 | 23.9 ± 3.1 | < 0.0001 |
| All patients (n = 8) | 38.1 ± 7.6 | 71.4 ± 6.5 | < 0.0001 | 6.5 ± 1.4 | 20.4 ± 2.0 | < 0.0001 |
| Patients . | Pre-tx F Cell % . | Max F Cell % . | P Value . | Pre-tx HbF % . | Max HbF % . | P Value . |
|---|---|---|---|---|---|---|
| Abbreviations: Tx, treatment; HU, hydroxyurea. | ||||||
| HU nonresponders (n = 3) | 16.2 ± 10.8 | 55.1 ± 11.1 | 0.002 | 2.4 ± 1.6 | 14.5 ± 2.2 | 0.0006 |
| HU responders (n = 5) | 51.3 ± 6.3 | 81.2 ± 4.4 | 0.0001 | 9.0 ± 2.5 | 23.9 ± 3.1 | < 0.0001 |
| All patients (n = 8) | 38.1 ± 7.6 | 71.4 ± 6.5 | < 0.0001 | 6.5 ± 1.4 | 20.4 ± 2.0 | < 0.0001 |