Results of KIR ligand incompatibility and outcome in recent clinical trials with non-HLA identical sibling stem cell transplants.
| . | . | . | Relapse % KIR Incompatible . | GVHD II–IV % KIR Incompatible . | DFS % KIR Incompatible . | |||
|---|---|---|---|---|---|---|---|---|
| Group . | Donor . | Patient (n) . | Yes . | No . | Yes . | No . | Yes . | No . |
| Abbreviations: ALL, acute lymphocytic leukemia; AML, acute myeloid leukemia; CML, chronic myelogenous leukemia; DFS, disease-free survival; GVHD, graft-versus-host disease; haplo ID, haploidentical T cell depleted transplants; KIR, killer immunoglobulin-like receptors; MDS, myelodysplastic syndrome; SCT, stem cell transplantation; URD, unrelated donor transplant; MM, multiple myeloma; NHL, non-Hodgkin’s lymphoma; HD, Hodgkin’s disease | ||||||||
| * (bold figures) significance at least P < .01 | ||||||||
| ** 5-year survivial. | ||||||||
| ‡ (bold figures) P = .07 | ||||||||
| Perugia7 | Haplo | AML (57) | 0** | 75 | 0 | 13.7 | 60 | 5** |
| ID | ALL (35) | 85 | 90 | |||||
| Minnesota26 | URD | Various (175) (CML, ALL, AML, MDS, nonmalignant) | 9 | 12 | 61 | 50 | 32 | 40** |
| Multicenter15 | URD | Various (135) (ALL, AML, CML, MDS, NHL, HD, MM) | 6 | 21‡ | 30 | 40 | 87 | 39* |
| . | . | . | Relapse % KIR Incompatible . | GVHD II–IV % KIR Incompatible . | DFS % KIR Incompatible . | |||
|---|---|---|---|---|---|---|---|---|
| Group . | Donor . | Patient (n) . | Yes . | No . | Yes . | No . | Yes . | No . |
| Abbreviations: ALL, acute lymphocytic leukemia; AML, acute myeloid leukemia; CML, chronic myelogenous leukemia; DFS, disease-free survival; GVHD, graft-versus-host disease; haplo ID, haploidentical T cell depleted transplants; KIR, killer immunoglobulin-like receptors; MDS, myelodysplastic syndrome; SCT, stem cell transplantation; URD, unrelated donor transplant; MM, multiple myeloma; NHL, non-Hodgkin’s lymphoma; HD, Hodgkin’s disease | ||||||||
| * (bold figures) significance at least P < .01 | ||||||||
| ** 5-year survivial. | ||||||||
| ‡ (bold figures) P = .07 | ||||||||
| Perugia7 | Haplo | AML (57) | 0** | 75 | 0 | 13.7 | 60 | 5** |
| ID | ALL (35) | 85 | 90 | |||||
| Minnesota26 | URD | Various (175) (CML, ALL, AML, MDS, nonmalignant) | 9 | 12 | 61 | 50 | 32 | 40** |
| Multicenter15 | URD | Various (135) (ALL, AML, CML, MDS, NHL, HD, MM) | 6 | 21‡ | 30 | 40 | 87 | 39* |