Recommended doses of growth factors.
| Cytokine . | Adults . | Pediatrics . | Pregnancy† . | Precautions . |
|---|---|---|---|---|
| Abbreviations: absolute neutrophil count (ANC), subcutaneous (SC), acute respiratory distress syndrome (ARDS), diffuse alveolar hemorrhage (DAH). | ||||
| †Any pregnant patient with radiation exposure should be evaluated by a health physicist to have the fetal exposure assessed. | ||||
| G-CSF or Filgrastim | 5 μg/kg per day as a SC injection started as early as possible and continued until ANC >1,000 | 5 μg/kg per day as a SC injection started as early as possible and continued until ANC >1,000 | Class C | Sickle cell hemoglobinopathies, signifcant coronary artery disease, ARDS. Consider discontinuation if pulmonary infiltrates develop at neutrophil recovery and assess for DAH. |
| Pegylated G-CSF or Pegfilgrastim | Give 6 mg SC × 1 dose | For adolescents > 45 kg: Give 6 mg SC × 1 dose | Class C | |
| GM-CSF or Sargramostim | 250 μg/m2 per day started as early as possible and continued until ANC > 1,000 | 250 μg/m2 per day started as early as possible and continued until ANC > 1,000 | Class C | |
| Cytokine . | Adults . | Pediatrics . | Pregnancy† . | Precautions . |
|---|---|---|---|---|
| Abbreviations: absolute neutrophil count (ANC), subcutaneous (SC), acute respiratory distress syndrome (ARDS), diffuse alveolar hemorrhage (DAH). | ||||
| †Any pregnant patient with radiation exposure should be evaluated by a health physicist to have the fetal exposure assessed. | ||||
| G-CSF or Filgrastim | 5 μg/kg per day as a SC injection started as early as possible and continued until ANC >1,000 | 5 μg/kg per day as a SC injection started as early as possible and continued until ANC >1,000 | Class C | Sickle cell hemoglobinopathies, signifcant coronary artery disease, ARDS. Consider discontinuation if pulmonary infiltrates develop at neutrophil recovery and assess for DAH. |
| Pegylated G-CSF or Pegfilgrastim | Give 6 mg SC × 1 dose | For adolescents > 45 kg: Give 6 mg SC × 1 dose | Class C | |
| GM-CSF or Sargramostim | 250 μg/m2 per day started as early as possible and continued until ANC > 1,000 | 250 μg/m2 per day started as early as possible and continued until ANC > 1,000 | Class C | |