Non-random chromosomal abnormalities in B-cell lymphomas.
| Lymphoma Subtype . | Nonrandom Chromosomal Alterations . | Genes Involved . | Assay Used for Diagnosis / Prognosis† . |
|---|---|---|---|
| Abbreviations: CLL/SLL, chronic lymphocytic leukemia/small lymphocytic lymphoma; LPL, lymphoplasmacytic lymphoma; MZL, marginal zone lymphoma; FL, follicular lymphoma; MCL, mantle cell lymphoma; DLBCL, diffuse large B-cell lymphoma; BL/BLL, Burkitt/Burkitt-like lymphoma. | |||
| †The assays listed are the most commonly used today for clinical testing today, but many of these abnormalities can also be detected by other techniques. | |||
| CLL/SLL | Del 13q14 | Unknown | FISH |
| Trisomy 12 | Unknown | FISH | |
| Del 11q22-23 | ATM | FISH | |
| Del 17p1 | TP53 | FISH, karyotyping | |
| LPL | t(9;14)(p13;q32) | PAX5/IgH | FISH, karyotyping |
| MZL | t(11;18)(q21;q21) | API2/MALT1 | FISH, PCR |
| t(1;14)(p22;q32) | BCL10/IgH | FISH, PCR | |
| t(14;18)(q32;q21) | IgH/MALT1 | FISH | |
| Trisomy 3 | ?BCL6 | FISH | |
| FL | t(14;18)(q32;q21) | IgH/BCL2 | PCR, FISH |
| MCL | t(11;14)(q13;q32) | Cyclin D1/IgH | FISH, PCR |
| DLBCL | 3q27 | BCL6 | FISH |
| t(14;18)(q32;q21) | IgH/BCL2 | FISH, PCR | |
| BL / BLL | t(8;14)(q24;q32) | c-MYC/IgH | FISH for c-MYC |
| t(2;8)(p11;q24) | Igk/c-MYC | FISH for c-MYC | |
| t(8;22)(q24;q11) | c-MYC/Igl | FISH for c-MYC | |
| Lymphoma Subtype . | Nonrandom Chromosomal Alterations . | Genes Involved . | Assay Used for Diagnosis / Prognosis† . |
|---|---|---|---|
| Abbreviations: CLL/SLL, chronic lymphocytic leukemia/small lymphocytic lymphoma; LPL, lymphoplasmacytic lymphoma; MZL, marginal zone lymphoma; FL, follicular lymphoma; MCL, mantle cell lymphoma; DLBCL, diffuse large B-cell lymphoma; BL/BLL, Burkitt/Burkitt-like lymphoma. | |||
| †The assays listed are the most commonly used today for clinical testing today, but many of these abnormalities can also be detected by other techniques. | |||
| CLL/SLL | Del 13q14 | Unknown | FISH |
| Trisomy 12 | Unknown | FISH | |
| Del 11q22-23 | ATM | FISH | |
| Del 17p1 | TP53 | FISH, karyotyping | |
| LPL | t(9;14)(p13;q32) | PAX5/IgH | FISH, karyotyping |
| MZL | t(11;18)(q21;q21) | API2/MALT1 | FISH, PCR |
| t(1;14)(p22;q32) | BCL10/IgH | FISH, PCR | |
| t(14;18)(q32;q21) | IgH/MALT1 | FISH | |
| Trisomy 3 | ?BCL6 | FISH | |
| FL | t(14;18)(q32;q21) | IgH/BCL2 | PCR, FISH |
| MCL | t(11;14)(q13;q32) | Cyclin D1/IgH | FISH, PCR |
| DLBCL | 3q27 | BCL6 | FISH |
| t(14;18)(q32;q21) | IgH/BCL2 | FISH, PCR | |
| BL / BLL | t(8;14)(q24;q32) | c-MYC/IgH | FISH for c-MYC |
| t(2;8)(p11;q24) | Igk/c-MYC | FISH for c-MYC | |
| t(8;22)(q24;q11) | c-MYC/Igl | FISH for c-MYC | |