Frequencies and stability of minimal residual disease polymerase chain reaction (MRD-PCR) targets in childhood precursor-B-cell acute lymphoblastic leukemia.
| . | . | . | Stability at Relapse** . | ||
|---|---|---|---|---|---|
| PCR Target . | Frequency at Diagnosis* . | Monoclonality at Diagnosis* . | Monoclonal . | Oligoclonal . | Total . |
| * see references 15-17. | |||||
| ** see reference 20. | |||||
| Abbreviations: NT, not tested. | |||||
| IGH | 95% | 60-70% | 85% | 44% | 64% |
| Vh-Jh | 95% | 88% | 47% | 69% | |
| Dh-Jh | 20% | 57% | 38% | 43% | |
| IGK-Kde | 50% | 90% | 95% | 40% | 90% |
| Vκ-Kde | 45% | 95% | 40% | 91% | |
| intron-Kde | 25% | 86% | 0 | 87% | |
| TCRG (Vγ-Jγ) | 55% | 60-65% | NT | NT | 75% |
| TCRD | 40% | 60% | 86% | 26% | 63% |
| Vδ2-Dδ3 | 35% | 81% | 31% | 63% | |
| Dδ2-Dδ3 | 7% | 100% | 14% | 63% | |
| . | . | . | Stability at Relapse** . | ||
|---|---|---|---|---|---|
| PCR Target . | Frequency at Diagnosis* . | Monoclonality at Diagnosis* . | Monoclonal . | Oligoclonal . | Total . |
| * see references 15-17. | |||||
| ** see reference 20. | |||||
| Abbreviations: NT, not tested. | |||||
| IGH | 95% | 60-70% | 85% | 44% | 64% |
| Vh-Jh | 95% | 88% | 47% | 69% | |
| Dh-Jh | 20% | 57% | 38% | 43% | |
| IGK-Kde | 50% | 90% | 95% | 40% | 90% |
| Vκ-Kde | 45% | 95% | 40% | 91% | |
| intron-Kde | 25% | 86% | 0 | 87% | |
| TCRG (Vγ-Jγ) | 55% | 60-65% | NT | NT | 75% |
| TCRD | 40% | 60% | 86% | 26% | 63% |
| Vδ2-Dδ3 | 35% | 81% | 31% | 63% | |
| Dδ2-Dδ3 | 7% | 100% | 14% | 63% | |